This product may be reconstituted in 0.01M phosphate buffer at pH 7.5. Stock solutions, prepared at 10 micro IU per milliliter, may be stored frozen in aliquots. Avoid repeated freeze/thaw cycles. Working solutions should be prepared fresh and not stored.
T9265
Thyrotropic hormone from human pituitary
lyophilized powder, ≥6.2 IU/mg (immunoassay, non-sterile)
Sinonimo/i:
hTSH, TSH, Thyroid stimulating hormone
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5 μG
149,00 €
10 μG
263,00 €
25 μG
523,00 €
0.1 MG
1.740,00 €
Scegli un formato
Cambia visualizzazione
5 μG
149,00 €
10 μG
263,00 €
25 μG
523,00 €
0.1 MG
1.740,00 €
About This Item
Prodotti consigliati
Origine biologica
human pituitary glands
Livello qualitativo
Sterilità
non-sterile
Stato
lyophilized powder
Attività specifica
≥6.2 IU/mg (immunoassay, non-sterile)
Condizioni di stoccaggio
(Keep container tightly closed in a dry and well-ventilated place)
tecniche
cell culture | mammalian: suitable
Impurezze
HIV Antibodies
Antibody to HCV
Antibody to HBV or Presence of HBSAG, tested negative
Condizioni di spedizione
ambient
Temperatura di conservazione
2-8°C
Informazioni sul gene
human ... TSHB(7252) , TSHR(7253)
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Descrizione generale
Research area: Cell Signaling
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family.[1] Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.[2]
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family.[1] Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.[2]
Applicazioni
Thyrotropic hormone from human pituitary has been used as a supplement in the fetal thyroid organoid culture medium for stimulating maturation.[3] It has also been used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.[4]
Azioni biochim/fisiol
In children, thyroid hormones are very much essential for the normal cognition and neurodevelopment.[5] Thyroid-stimulating hormone (TSH) test is mainly used to diagnose thyroid function.[6]
The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer celllines.[7]TSHR activated by TSH activates both the adenosine 3′,5′-cyclic monophosphate (cAMP) pathway (via Gsa) and the phosphoinositol/calcium (IP/Ca2+; via Gq) second messenger signaling pathway by interacting with Gs and Gq G-proteins.[8] In mature adipocytes, TSH aids in lipid metabolism by inhibiting fatty acid synthase (FASN) expression via, activating protein kinase A (PKA)-dependent phosphorylation of extracellular signal-regulated kinases/p42/p44 (ERK1/2), and c-Jun N-terminal kinase (JNK).[9]
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
Confezionamento
Package size based on hormone
Stato fisico
Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.
Anticorpo
N° Catalogo
Descrizione
Determinazione del prezzo
Prodotti correlati
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
D Manole et al.
The Journal of clinical endocrinology and metabolism, 86(3), 1072-1077 (2001-03-10)
Thyroid tumors are about 3 times more frequent in females than in males. Epidemiological studies suggest that the use of estrogens may contribute to the pathogenesis of thyroid tumors. In a very recent study a direct growth stimulatory effect of
Physiology, Thyroid Stimulating Hormone
Pirahanchi Y, et al.
StatPearls [Internet] (2022)
Zhenghao Wu et al.
Journal for immunotherapy of cancer, 10(1) (2022-02-02)
Hormones are identified as key biological variables in tumor immunity. However, previous researches mainly focused on the immune effect of steroid hormones, while the roles that thyroid-stimulating hormone (TSH) played in the antitumor response were far from clear. The source
Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships
Szkudlinski MW, et al.
Physiological Reviews, 82(2), 473-502 (2002)
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