T6031

DL-Thiorphan

≥98% (TLC)

• Sinonimo/i: (±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine
• Formula empirica (notazione di Hill): C₁₂H₁₅NO₃S
• Numero CAS: 76721-89-6
• Peso molecolare: 253.32
• Beilstein: 4872101
• Numero MDL: MFCD00058435
• Codice UNSPSC: 12352200
• ID PubChem: 24278747
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (TLC)
• Stato: powder
• Punto di fusione: 138 °C
• Solubilità: ethanol: soluble 49.00-51.00 mg/mL, clear, colorless
• Stringa SMILE: OC(=O)CNC(=O)C(CS)Cc1ccccc1
• InChI: 1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15); LJJKNPQAGWVLDQ-UHFFFAOYSA-N
• Informazioni sul gene: human ... ACE(1636) , ECE1(1889) ; rat ... Ace(24310) , Mme(24590)

Descrizione

Descrizione generale

Thiorphan, also called DL-mercapto-2-benzylpropanoyl-glycine is a specific and potent inhibitor of enkephalinase in nanomolar concentrations.[1] It is an inhibitor of neutral endopeptidase. It interacts with cluster of differentiation 10 (CD10) in bone marrow cells and may modulate hematopoiesis.[2] Thiorphan is a safe drugprescribed for diarrhea. It prevents cortical damage in newborn mice and is a potent agent for treating cerebral palsy.(CP)[3]

Applicazioni

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase.[4] DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.[5]

Azioni biochim/fisiol

Enkephalinase inhibitor.

Caratteristiche e vantaggi

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)