This haptoglobin product is lyophilized from a solution containing 0.269 % Trehalose, 0.727 % Dibasic mono hydrogen potassium phosphate, and 0.248 % Monobasic dihydrogen potassium phosphate.
SRP6507
Haptoglobin (Phenotype 1-1) from human plasma
≥95% (SDS-PAGE)
Sinonimo/i:
Hp 1-1
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About This Item
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Descrizione generale
Haptoglobin is a positive acute-phase plasma α2-sialoglycoprotein, and exists as three major phenotypes namely Hp 1-1, Hp 2-1, and Hp 2-2. Haptoglobin is composed of heavy β- (40 kDa) and light α- (α1= 8.9kDa and α2= 16kDa) chains. Hp 1-1 is the smallest phenotype with a molecular weight of 86kDa, and is composed of only α1.[1][2][3]
Azioni biochim/fisiol
Haptoglobin functions as an antioxidant by binding free hemoglobin, and eliminates it from circulation to prevent iron loss and renal injury following hemolysis. It is responsible for maintaining the helper T-cell type 1 and type 2 (Th1/Th2) balance, and functions as an immunosuppressor of lymphocyte function. It also functions as an angiogen and anti-inflammatory agent. Hp 1-1 phenotype is most effective in binding free hemoglobin and preventing inflammatory responses linked with free hemoglobin.[1][2] Studies show that all the three phenotypes of haptoglobin are involved in idiopathic generalized epilepsy.[3]
Stato fisico
Lyophilized as a salt-free solid.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Haptoglobin phenotypes in epilepsy.
Sadrzadeh SM, et al.
Clinical Chemistry, 50(6), 1095-1097 (2004)
Haptoglobin phenotypes in health and disorders.
Sadrzadeh SM, Bozorgmehr J, et al.
American Journal of Clinical Pathology, 121, S97-104 (2004)
Determination of haptoglobin genotype in an Iranian population with idiopathic generalized epilepsy.
Al-Balaghee S et al
Reports of Biochemistry and Molecular Biology, 3(2), 51-55 (2015)
Fabiana Baganha et al.
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凍結乾燥時の組成を教えていただきたく存じます（濃度は不要です）。 当該物質を用いた試験法を構築中ですが、組成による試験系の妨害を懸念しております。
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