SRP5075
PTPN2, active, GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinonimo/i:
PTPT, TCELLPTP, TCPTP
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10 μG
333,00 €
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Cambia visualizzazione
10 μG
333,00 €
About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Ricombinante
expressed in E. coli
Saggio
≥70% (SDS-PAGE)
Stato
buffered aqueous glycerol solution
Attività specifica
6928-9372 nmol/min·mg
PM
~69 kDa
N° accesso NCBI
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... PTPN2(5771)
Descrizione generale
Research Area: Cell Signaling
Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction.
Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction.
Azioni biochim/fisiol
Protein tyrosine phosphatase, non-receptor type 2 (PTPN2) regulates interferon signaling and the endoplasmic reticulum stress response in pancreatic β-cells during autoimmune diabetes.[1] It serves as a crucial prognostic marker that influences the progression of pancreatic adenocarcinoma (PAAD) by activating the JAK-STAT signaling pathway. Silencing PTPN2 leads to a significant reduction in PAAD cell growth, migration, and invasion, while also triggering cell cycle arrest and apoptosis in PAAD cells.[2]
Stato fisico
Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.
Nota sulla preparazione
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
PTPN2, A key predictor of prognosis for pancreatic adenocarcinoma, significantly regulates cell cycles, apoptosis, and metastasis
Kuang W, et al.
Frontiers in Immunology, 13, 805311-805311 (2022)
PTPN2 regulates the interferon signaling and endoplasmic reticulum stress response in pancreatic beta cells in autoimmune diabetes
Elvira B, et al.
Diabetes, 71(4), 653-668 (2022)
Tetsuya Yamamoto et al.
Biochemical and biophysical research communications, 297(4), 811-817 (2002-10-03)
In the previous study, we demonstrated that the nuclear isoform of T-cell protein-tyrosine phosphatase (TC-PTP) dephosphorylated and deactivated signal transducer and activator of transcription 5a (STAT5a) and STAT5b, thereby negatively regulating prolactin (PRL)-mediated signaling pathway. In this study, we examined
Sanjeev Gupta et al.
FEBS letters, 532(1-2), 61-66 (2002-12-03)
PTP-S2/TC45 is a nuclear protein tyrosine phosphatase, which induces p53-dependent apoptosis. Here we show that the p53 protein level increased in MCF-7 cells in response to PTP-S2 overexpression. PTP-S2-induced p53 protein was transcriptionally active and it could activate caspase-1 gene
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