SML1376
BTC
≥95% (HPLC)
Sinonimo/i:
2-(4-Hydroxyphenyl)-1-benzothiophene-6-ol, 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
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About This Item
Formula empirica (notazione di Hill):
C14H10O2S
Numero CAS:
Peso molecolare:
242.29
Codice UNSPSC:
51111800
NACRES:
NA.77
Prodotti consigliati
Saggio
≥95% (HPLC)
Stato
powder
Condizioni di stoccaggio
protect from light
Colore
white to light brown
Solubilità
DMSO: 20 mg/mL, clear
Temperatura di conservazione
−20°C
InChI
1S/C14H10O2S/c15-11-4-1-9(2-5-11)13-7-10-3-6-12(16)8-14(10)17-13/h1-8,15-16H
MDGWZLQPNOETLH-UHFFFAOYSA-N
Azioni biochim/fisiol
BTC is a selective estrogen receptor (ER) modulator (SERM) that acts as a selective estrogen mimic (SEM).
BTC is a selective estrogen receptor (ER) modulator (SERM) that acts as a selective estrogen mimic (SEM). BTC has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα), which is often associated with tamoxifen resistance. BTC caused regression of endocrine-resistant breast cancer xenografts, and did not support the growth of hormone-dependent xenografts in vivo or cause an increase in uterine weight. As in the case with raloxifene and estradiol, BTC tumor regression was accompanied by the exit of ERα from the nucleus, suggesting extranuclear ERα may be involved in the mehanism of action.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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