SML0982

Astaxanthin

≥97% (HPLC), powder, PPARγ

• Sinonimo/i: 3,3′-Dihydroxy-β-carotene-4,4′-dione, trans-Astaxanthin
• Formula empirica (notazione di Hill): C₄₀H₅₂O₄
• Numero CAS: 472-61-7
• Peso molecolare: 596.84
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Nome del prodotto: Astaxanthin, ≥97% (HPLC)
• Saggio: ≥97% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated; protect from light
• Colore: , pink to very dark purple
• Solubilità: DMSO: 1 mg/mL (warmed)
• Temperatura di conservazione: −20°C
• Stringa SMILE: O[C@H]1CC(C(=C(C1=O)C)\C=C\C(=C\C=C\C(=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C2=C(C(=O)[C@H](CC2(C)C)O)C)\C)\C)(C)C
• InChI: 1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1; MQZIGYBFDRPAKN-UWFIBFSHSA-N

Descrizione

Descrizione generale

Astaxanthin (AST) is a red dietary carotenoid. It is mainly found in aquatic animals and microalgae, such as Haematococcus pluvialis and Chlorella zofingiensis.[1]

Applicazioni

Astaxanthin has been used:

• as an antioxidant to study its effect on Brachionus manjavacas (Rotifera) population growth[2]
• to study its effects on the treatment of diabetic retinopathy.[2][3]
• to investigate its role in restoring the expression of Nrf2 (nuclear factor erythroid 2 p45-related factor 2) and glutathione S-transferase P1 (GSTP1) through epigenetic modification in human prostate LNCaP cells.[1]

Azioni biochim/fisiol

In vivo and in vitro studies propose that astaxanthin (AST) possesses health-promoting activities, signifying its potential use in the prevention of various diseases, such as cancers and Parkinson′s disease.[1] Due to its bright red colour, AST has been used as a food colorant in animal feeds.[3]

Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.

Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin protects against oxidative stress, inhibiting NF-KB, suppressing pro-inflammatory genes and suppressing production of pro-inflammatory compounds nitric oxide, prostaglandin E2, TNF-α, and interleukin-1β. Astaxanthin′s protection of cells from oxidative stress generated by TNF-α and palmitate has been shown to ameliorate insulin resistance. Astaxanthin has also been shown to be an inhibitor of PPARγ.

Altre note

Light and air sensitive

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable