SAB5200022
Monoclonal Anti-CACNA1D antibody produced in mouse
clone S48A-9, 1 mg/mL, purified immunoglobulin
Sinonimo/i:
Anti-CACH3, Anti-CACN4, Anti-CACNA 1D, Anti-CACNL1A2, Anti-Cav1.3, S48A-9, Anti-oltage dependent L type calcium channel subunit alpha 1D
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Coniugato
unconjugated
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
S48A-9, monoclonal
Forma fisica
buffered aqueous glycerol solution
PM
antigen predicted mol wt 250 kDa
Reattività contro le specie
human, rat, mouse
Concentrazione
1 mg/mL
tecniche
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotipo
IgG2aκ
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
rat ... Cacna1d(29716)
Descrizione generale
Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is expressed in many tissues and possesses six transmembrane segments, along with a loop lining the pore of the channel. The gene encoding CACNA1D is localized on human chromosome 3p14.3.
Specificità
Detects ~250 kDa. No cross-reactivity against Cav1.2
Immunogeno
Fusion protein amino acids 859-875 of rat Cav1.3, Accession Number P27732
Applicazioni
Monoclonal Anti-CACNA1D antibody produced in mouse has been used in immunocytochemistry.
Azioni biochim/fisiol
Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is crucial for the functioning of the brain and in hearing. It gets activated at a fast rate and withstands high inward Ca2+ currents even at threshold voltages. CACNA1D aids in dendritic signals linked to mitochondrial stress in the brain and is important for estrogen-stimulated Ca2+ influx. Studies have shown that in atrial myocytes, the C terminus of the channel translocates to the nucleus and regulates Ca2+-activated K+ channels. CACNA1D was shown to be upregulated in endometrial cancer and its knockdown showed a reduction in cell proliferation in vitro. Mutations in the gene encoding it has been associated with aldosterone-producing adenomas (APAs), where it leads to the formation of small adenomas.
Caratteristiche e vantaggi
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Stato fisico
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Juan Hao et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(7), 2883-2893 (2015-03-26)
Calcium and calcium channels are closely related to the estrogen-induced nongenomic effect of endometrial carcinoma, but the specific role of calcium channels is unknown. This study aimed to explore the expression and the biologic effect of the L-type calcium channel
Fabio Luiz Fernandes-Rosa et al.
Hypertension (Dallas, Tex. : 1979), 64(2), 354-361 (2014-05-29)
Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone-producing adenomas (APAs). Our aim was to investigate the prevalence of somatic mutations in these genes in unselected
Assignment of the gene encoding the alpha 1 subunit of the neuroendocrine/brain-type calcium channel (CACNL1A2) to human chromosome 3, band p14.3.
S Seino et al.
Genomics, 13(4), 1375-1377 (1992-08-01)
Andreas Lieb et al.
Biophysical journal, 106(7), 1467-1475 (2014-04-08)
Activity of voltage-gated Cav1.3 L-type Ca(2+) channels is required for proper hearing as well as sinoatrial node and brain function. This critically depends on their negative activation voltage range, which is further fine-tuned by alternative splicing. Shorter variants miss a
Ling Lu et al.
The Journal of biological chemistry, 290(8), 4663-4676 (2014-12-30)
Cav1.3 L-type Ca(2+) channel is known to be highly expressed in neurons and neuroendocrine cells. However, we have previously demonstrated that the Cav1.3 channel is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-specific
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