Cortactin is an actin-related protein 2/3 (Arp2/3) complex–activating and filamentous (F)-actin–binding protein. This protein is coded by CTTN gene that maps to human chromosome 11q13.
Immunogeno
The antiserum was produced against synthesized peptide derived from human Cortactin around the phosphorylation site of Tyr421.
Immunogen Range: 388-437
Applicazioni
Anti-phospho-Cortactin (pTyr421) antibody has been used in western blotting and immunoprecipitation.
Azioni biochim/fisiol
Cortactin controls Arp2/3-mediated actin polymerization. This protein also modulates aggressive cancer cell traits like tumor growth, cancer cell invasion and motility, and serum- and anchorage-independent growth.
Caratteristiche e vantaggi
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Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The primary cilium, critical for morphogenic and growth factor signaling, is assembled upon cell cycle exit, but the links between ciliogenesis and cell cycle progression are unclear. KV10.1 is a voltage-gated potassium channel frequently overexpressed in tumors. We have previously
Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification.
Rothschild B L, et al.
Cancer Research, 66(16), 8017-8025 (2006)
Cortactin contributes to the tumorigenicity of colorectal cancer by promoting cell proliferation.
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