C0739
Anti-phospho-Cortactin (pTyr421) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
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938,00 €
938,00 €
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Cambia visualizzazione
1 VIAL
938,00 €
About This Item
938,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous glycerol solution
PM
antigen 80-85 kDa
Reattività contro le specie
mouse
tecniche
immunocytochemistry: suitable
western blot: 1:1,000
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
phosphorylation (pTyr421)
Informazioni sul gene
mouse ... Cttn(13043)
Descrizione generale
Cortactin is encoded by the CTTN gene on chromosome 11 in humans. It is a cytoskeleton protein that facilitates assembly of cortical actin. It is expressed in most adherent cells and is a prominent substrate of protein-tyrosine kinase Src.
Immunogeno
synthetic phosphopeptide derived from the region of mouse cortactin that is phosphorylated on tyrosine 421.
Applicazioni
Anti-phospho-Cortactin (pTyr421) antibody produced in rabbit is suitable for immunocytochemistry and western blotting at a working dilution of 1:1,000
Azioni biochim/fisiol
Cortactin is activated by phosphorylation of tyrosine kinases or serine/threonine kinases. It plays an important role in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis. Cortactin regulates the interactions between components of adherens-type junctions and helps in organizing the cytoskeleton, cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. It acts as a regulator in invasion and migration of tumor cells. The overexpression of cortactin causes osteosarcoma carcinogenesis and along with FAK increases the risk of oral premalignant lesions.
Stato fisico
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3 (+/- 0.1), 50% glycerol with 1.0 mg/mL bovine serum albumin (IgG and protease free) and 0.05% sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Maxwell D Weidmann et al.
Scientific reports, 6, 36142-36142 (2016-11-09)
Invadopodia, actin-based protrusions of invasive carcinoma cells that focally activate extracellular matrix-degrading proteases, are essential for the migration and intravasation of tumor cells during dissemination from the primary tumor. We have previously shown that cortactin phosphorylation at tyrosine residues, in
Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival.
Cecilia Folio et al.
Cancer biomarkers : section A of Disease markers, 10(1), 35-41 (2012-02-03)
The cortactin (CTTN) gene has been found, by transcriptomic profiling, to be overexpressed in pediatric osteosarcoma. The location of CTTN at 11q13 and the role of cortactin in cytoskeleton restructuring make CTTN of interest as a potential biomarker for osteosarcoma.
Aviv Bergman et al.
Cell adhesion & migration, 8(3), 273-279 (2014-04-10)
Invadopodia are dynamic protrusions in motile tumor cells whose function is to degrade extracellular matrix so that cells can enter into new environments. Invadopodia are specifically identified by microscopy as proteolytic invasive protrusions containing TKS5 and cortactin. The increasing complexity
Roger J Daly
The Biochemical journal, 382(Pt 1), 13-25 (2004-06-10)
Cortactin was first identified over a decade ago, and its initial characterization as both an F-actin binding protein and v-Src substrate suggested that it was likely to be a key regulator of actin rearrangements in response to tyrosine kinase signalling.
Cortactin is a sensitive biomarker relative to the poor prognosis of human hepatocellular carcinoma.
Gang Zhao et al.
World journal of surgical oncology, 11, 74-74 (2013-03-23)
Cortactin is an important regulator involved in invasion and migration of hepatocellular carcinoma (HCC). The aim of this study was to elucidate the forecasting role of cortactin in resectable HCCs. We compared the invasiveness and motility among liver epithelial cell
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