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S4441

Sigma-Aldrich

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

Sinonimo/i:

1-Isothiocyanato-4-(methylsulfinyl)-butane

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5 MG
188,00 €

188,00 €

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5 MG
188,00 €

About This Item

Formula empirica (notazione di Hill):
C6H11NOS2
Numero CAS:
4478-93-7
Peso molecolare:
177.29
Numero MDL:
MFCD00198068
Codice UNSPSC:
12352200
ID PubChem:
24724610
NACRES:
NA.77

188,00 €

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Nome del prodotto

DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid

Origine biologica

synthetic

Saggio

≥90% (HPLC)

Stato

liquid

Solubilità

DMSO: soluble 40 mg/mL
H2O: insoluble

Compatibilità

for use with ABI 7500

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

CS(=O)CCCCN=C=S

InChI

1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
SUVMJBTUFCVSAD-UHFFFAOYSA-N

Applicazioni

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor.[1] Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.[2]

Azioni biochim/fisiol

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.
Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables.[3][4] It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.[3][5]

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000409450
0000409450
0000398399
0000371801
0000361084

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International journal of molecular medicine, 38(6), 1940-1946 (2016-11-15)
β-caryophyllene, which is a constituent of many essential oils, has been known to be a selective agonist of the cannabinoid receptor type-2 and to exert cannabimimetic anti-inflammatory effects in animals. The effects of β-caryophyllene on macrophages have not been investigated
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Mutation research, 635(2-3), 90-104 (2006-12-01)
A number of natural compounds with inhibitory effects on tumorigenesis have been identified from our diet. Several studies have documented the cancer-preventive activity of a significant number of isothiocyanates (ITCs), the majority of which occur in plants, especially in Cruciferous
A Kenneth MacLeod et al.
British journal of cancer, 115(12), 1530-1539 (2016-11-09)
Although the nuclear factor-erythroid 2-related factor 2 (NRF2) pathway is one of the most frequently dysregulated in cancer, it is not clear whether mutational status is a good predictor of NRF2 activity. Here we utilise four members of the aldo-keto
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Multiple lepidopteran larvae feed successfully on plants containing glucosinolates despite the diverse array of toxic and deterrent breakdown products, such as isothiocyanates (ITCs), formed upon plant damage. While much is known about how specialist lepidopterans metabolize and tolerate glucosinolates, there
Y Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(6), 2399-2403 (1992-03-15)
Consumption of vegetables, especially crucifers, reduces the risk of developing cancer. Although the mechanisms of this protection are unclear, feeding of vegetables induces enzymes of xenobiotic metabolism and thereby accelerates the metabolic disposal of xenobiotics. Induction of phase II detoxication
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