S4139
Spermidine
BioReagent, suitable for cell culture
Sinonimo/i:
1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
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About This Item
Formula condensata:
NH2(CH2)3NH(CH2)4NH2
Numero CAS:
Peso molecolare:
145.25
Beilstein:
1698591
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
Prodotti consigliati
Nome Commerciale
BioReagent
Saggio
≥98% (GC)
Stato
solid
tecniche
cell culture | mammalian: suitable
Colore
clear colorless to light yellow-white
Indice di rifrazione
n20/D 1.479 (lit.)
Densità
0.925 g/mL at 25 °C (lit.)
Temperatura di conservazione
2-8°C
Stringa SMILE
NCCCCNCCCN
InChI
1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
ATHGHQPFGPMSJY-UHFFFAOYSA-N
Informazioni sul gene
rat ... Ppm1a(24666)
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Azioni biochim/fisiol
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine together with putrescine and spermine compose a family of biogenic polyamines (polycations) that are required for the survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycan, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols. Spermidine Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.
Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.
Avvertenza
Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Skin Corr. 1B
Codice della classe di stoccaggio
8A - Combustible corrosive hazardous materials
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
233.6 °F - closed cup
Punto d’infiammabilità (°C)
112 °C - closed cup
Dispositivi di protezione individuale
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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