As reported in the 'DESCRIPTION' section of the product page, Sulfatide is a 3-O-sulfogalactosylceramide consisting primarily of galacto cerebroside sulfate. This product has not been further characterized.
S1006
Sulfatides from bovine brain
≥97% (TLC), powder
Sinonimo/i:
Cerebroside sulfate
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5 MG
312,20 €
10 MG
827,00 €
50 MG
2.140,00 €
312,20 €
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5 MG
312,20 €
10 MG
827,00 €
50 MG
2.140,00 €
About This Item
Codice UNSPSC:
12352200
NACRES:
NA.77
312,20 €
Prezzo di listino446,00 €Risparmia il 30%Per informazioni sulla disponibilità, contatta il Servizio Clienti.
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Prodotti consigliati
Nome del prodotto
Sulfatides from bovine brain,
Livello qualitativo
Temperatura di conservazione
−20°C
Descrizione generale
Sulfatideis a glycospingolipid and plays an essential role in host-pathogen recognition,β-cell function, infection, haemostasis/thrombosis, protein trafficking, cellgrowth, cell adhesion, neuronal plasticity, cell morphogenesis, and signaltransduction.[1][2] It is found on the surface of the blood cells such asplatelets, leukocytes, and erythrocytes. Sulfatides are also found in the serumas glycosphingolipids in lipoproteins.[3] It is made up of glycan part, a hydrophobic part, 3-O-sulfated galactose, and ceramide, which in turn is composed of a sphingosine base and a fatty acid.[1] It is an important component forthe maintenance of the myelin sheath andproper formation of the axo-glial junctions. Variations in the production ofsulfatides are associated with various human diseases like cancer andimmunological disorders. Alterations in the sulfatide metabolism lead to synapticdysfunction, neurological decline, inflammation, and myelin deterioration.[1]
Sulfatide is a 3-O-sulfogalactosylceramide consisting primarily of galacto cerebroside sulfate. It is localized in myelin sheath and comprises approximately 4% of total myelin lipid in brain.[4]
Applicazioni
Azioni biochim/fisiol
Sulfatides play a key role in physiological processes of nervous system, immune system and in insulin secretion.[4] Anomalies in sulfatides catabolism in lysosome is implicated in late infantile metachromatic leukodystrophy.[8] High levels of sulfatides is also observed in ovarian cancer.[9] Sulfatides contribute to the pathogenesis of chronic inflammatory diseases of the central nervous system.[10]
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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I clienti hanno visto anche
Age-and brain region-specific effects of dietary vitamin K on myelin sulfatides
Crivello NA, et al.
The Journal of Nutritional Biochemistry, 21(11), 1083-1088 (2010)
Sulfatide-binding assay for von Willebrand factor: detection of von Willebrand's disease without discrimination of vWD subtypes
Favaloro EJ
Thrombosis Research, 98(2), 213-219 (2000)
Maria Blomqvist et al.
Molecular and cellular neurosciences, 116, 103670-103670 (2021-09-26)
Sulfatide (3-O-sulfogalactosylceramide, SM4) is a glycosphingolipid, highly multifunctional and particularly enriched in the myelin sheath of neurons. The role of sulfatide has been implicated in various biological fields such as the nervous system, immune system, host-pathogen recognition and infection, beta
Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry
Liu Y, et al.
Molecular Cancer, 9(1), 186-186 (2010)
Quantification of sulfatides and lysosulfatides in tissues and body fluids by liquid chromatography tandem mass spectrometry
Mirzaian M, et al.
Journal of Lipid Research, 56(8), 936-943 (2015)
Articoli
Discover Bioactive Small Molecules for Lipid Signaling Research
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Hi, Do you have any information about the sulfatide composition/profile of “Sulfatide from bovine brain (S1006)”.
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