S0441

SB-366791

≥98% (HPLC), powder

• Sinonimo/i: N-(3-Methoxyphenyl)-4-chlorocinnamide
• Formula empirica (notazione di Hill): C₁₆H₁₄NO₂Cl
• Numero CAS: 472981-92-3
• Peso molecolare: 287.74
• Numero MDL: MFCD01033818
• Codice UNSPSC: 12352200
• ID PubChem: 24278690
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 5 mg/mL, clear
• Ideatore: GlaxoSmithKline
• Stringa SMILE: COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1
• InChI: 1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+; RYAMDQKWNKKFHD-JXMROGBWSA-N
• Informazioni sul gene: human ... TRPV1(7442)

Descrizione

Applicazioni

SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist:

• to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810)[1]
• to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activity[2]
• to study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)[3]

Azioni biochim/fisiol

SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.[4]

Vanilloid receptor-1 (TRPV1) antagonist.

Caratteristiche e vantaggi

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)