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RAB1351

Sigma-Aldrich

Human CD74 ELISA

for serum, plasma and cell culture supernatants

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About This Item

Codice UNSPSC:
41116158
NACRES:
NA.32

Reattività contro le specie

human

Confezionamento

kit of 96 wells (12 strips x 8 wells)

tecniche

ELISA: suitable

input

sample type plasma
sample type cell culture supernatant(s)
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.1 ng/mL
standard curve range: 0.102-25 ng/mL

Metodo di rivelazione

colorimetric

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... CD74(972)

Descrizione generale

The CD74 (HLA-DR (human leukocyte antigen – antigen D related) antigens-associated invariant chain) gene encodes for a type II transmembrane protein and is expressed by antigen presenting cells such as monocytes, B cells, macrophages and dendritic cells. The CD74 gene is mapped to human chromosome 5q33.1.

Applicazioni

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Azioni biochim/fisiol

CD74 (HLA-DR (human leukocyte antigen – antigen D related) antigens-associated invariant chain) is part of major histocompatibility complex (MHC) class II and its function is associated with antigen presentation. Upregulation of the CD74 gene is observed cancer including breast cancer and it is known to promote to metastasis. CD74 also serves as a cytokine receptor in immune and epithelial cells. It induces cellular processes such as cell proliferation, migration and survival pathways.

Altre note

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Pittogrammi

Corrosion
GHS05

Avvertenze

Warning

Indicazioni di pericolo

H290

Consigli di prudenza

P234 - P390

Classi di pericolo

Met. Corr. 1

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Van?den Berghe?s 5q?syndrome in 2008.
Mohamedali A and Mufti G J
British Journal of Haematology, 144(2), 157-168 (2009)
CD74 and intratumoral immune response in breast cancer.
Wang Z Q, et al.
Oncotarget, 8(8), 12664-12664 (2017)
Gabriela Athziri Sánchez-Zuno et al.
Journal of clinical medicine, 11(1) (2022-01-12)
Macrophage migration inhibitory factor (MIF) significantly contributes to rheumatoid arthritis (RA) pathogenesis. We aimed to evaluate the canonical (CD74/CD44) and non-canonical MIF receptors (CXCR2,4 and 7) expression and sCD74 to establish their association with RA clinical activity according to DAS28-ESR.
GSK-3?-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63.
Park G B, et al.
International Journal of Oncology, 49(5), 2163-2172 (2016)
Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74.
Meza-Romero R, et al.
Cytokine, 88, 62-70 (2016)
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