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PZ0162

Sigma-Aldrich

PD 0325901

≥98% (HPLC)

Sinonimo/i:

N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

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About This Item

Formula empirica (notazione di Hill):
C16H14F3IN2O4
Numero CAS:
391210-10-9
Peso molecolare:
482.19
Numero MDL:
MFCD08435926
Codice UNSPSC:
12352200
ID PubChem:
329823743
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Saggio

≥98% (HPLC)

Stato

powder

Attività ottica

[α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol

Colore

white to off-white

Solubilità

DMSO: 20 mg/mL, clear

Temperatura di conservazione

2-8°C

Stringa SMILE

FC1=C(NC2=CC=C(I)C=C2F)C(C(NOC[C@H](O)CO)=O)=CC=C1F

InChI

1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
SUDAHWBOROXANE-SECBINFHSA-N

Informazioni sul gene

human ... MAP2K1(5604) , MAP2K2(5605)

Applicazioni

PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells,[1] RKO colorectal cancer cell line[2] and human embryonic stem cells(hESCs).[3]

Azioni biochim/fisiol

PD 0325901 by inhibiting mitogen-activated protein kinases (MAPKs) elicits growth-inhibitory and antiangiogenic effects on glioblastoma[4] and melanoma tumor progression.[5]
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor.
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.

Caratteristiche e vantaggi

This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301,H373,H413

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Chronic 4 - STOT RE 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000338680
0000243126
0000338680
0000243126
0000212164

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iPSC Induction Enhancer, Thiazovivin A cell-permeable aminothiazolo-carboxamide compound that is reported to augment SB431542 and PD0325901.

Millipore

420220-M

iPSC Induction Enhancer, Thiazovivin

CHIR 98014 ≥98% (HPLC)

Sigma-Aldrich

SML1094

CHIR 98014

XAV939 ≥98% (HPLC)

Sigma-Aldrich

X3004

XAV939

ESGRO-2i Medium, 100ml to enhance viability of mouse embryonic stem and iPS cells

Sigma-Aldrich

SF016

ESGRO-2i Medium, 100ml

SB 431542 ≥98% (HPLC), powder

Sigma-Aldrich

S4317

SB 431542

Proteina LIF ricombinante di topo ESGRO® ESGRO Leukemia Inhibitory Factor (LIF) supplement for mouse ES cell culture. Each vial contains 10^7 units/ml.

Sigma-Aldrich

ESG1107

Proteina LIF ricombinante di topo ESGRO®

Proteina LIF ricombinante di topo ESGRO® ESGRO Leukemia Inhibitory Factor (LIF) supplement for mouse ES cell culture. Each vial contains 10^6 units/ml

Sigma-Aldrich

ESG1106

Proteina LIF ricombinante di topo ESGRO®

Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations
Ciuffreda L, et al.
Neoplasia, 11(8), 720-W6-720-W6 (2009)
Feeder-Free Derivation of Naive Human Pluripotent Stem Cells
Ward E, et al.
Stem Cells and Development, 26(15), 1087-1089 (2017)
Madeleine Linneberg-Agerholm et al.
Development (Cambridge, England), 146(24) (2019-11-20)
Embryonic stem cells (ESCs) exist in at least two states that transcriptionally resemble different stages of embryonic development. Naïve ESCs resemble peri-implantation stages and primed ESCs the pre-gastrulation epiblast. In mouse, primed ESCs give rise to definitive endoderm in response
Inhibition of glioblastoma dispersal by the MEK inhibitor PD0325901
Shannon S, et al.
BMC Cancer, 17(1), 121-121 (2017)
Bin Zhang et al.
The Journal of clinical investigation, 126(3), 975-991 (2016-02-16)
Chronic myelogenous leukemia (CML) results from transformation of a long-term hematopoietic stem cell (LTHSC) by expression of the BCR-ABL fusion gene. However, BCR-ABL-expressing LTHSCs are heterogeneous in their capacity as leukemic stem cells (LSCs). Although discrepancies in proliferative, self-renewal, and
Visualizza tutti i documenti correlati

Articoli

MAPKKKs

The extracellular signal regulated kinase (ERK1 and ERK2) pathways are activated by mitogens and play an important role in controlling cell growth and differentiation.

Naive Pluripotent Stem Cell Culture in Serum-Free Media

Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.

Domande

Recensioni

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