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Merck
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Documenti

444968

Sigma-Aldrich

PD0325901

≥95% (HPLC), liquid, MEK1/2 inhibitor, Calbiochem®

Sinonimo/i:

InSolution MEK1/2 Inhibitor III, PD0325901, PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901

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About This Item

Formula empirica (notazione di Hill):
C16H14F3IN2O4
Numero CAS:
Peso molecolare:
482.19
Numero MDL:
Codice UNSPSC:
12352200
NACRES:
NA.77

product name

MEK1/2 Inhibitor III, PD0325901, InSolution, ≥95%

Livello qualitativo

Saggio

≥95% (HPLC)

Forma fisica

liquid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
desiccated (hygroscopic)
protect from light

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

InChI

1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
SUDAHWBOROXANE-SECBINFHSA-N

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Regulatory Review (Z)

Stato fisico

A 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

188.6 °F - closed cup - (refers to pure substance)

Punto d’infiammabilità (°C)

87 °C - closed cup - (refers to pure substance)


Certificati d'analisi (COA)

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Zhao Yang et al.
Journal of biochemical and molecular toxicology, 36(12), e23219-e23219 (2022-09-20)
Polyphyllin I (PPI) is a famous traditional medicine ingredient, which has been explored in wide range of areas. Nevertheless, whether PPI exerts any functions in coronary artery disease (CAD) is still uncertified. Herein, we probed the effect and mechanism of
Gayan I Balasooriya et al.
Nature communications, 13(1), 5984-5984 (2022-10-11)
Each mammalian autosomal gene is represented by two alleles in diploid cells. To our knowledge, no insights have been made in regard to allele-specific regulatory mechanisms of autosomes. Here we use allele-specific single cell transcriptomic analysis to elucidate the establishment
Andrew D Economou et al.
Developmental cell, 57(23), 2604-2622 (2022-12-07)
Specification of the germ layers by Nodal signaling has long been regarded as an archetype of how graded morphogens induce different cell fates. However, this deterministic model cannot explain why only a subset of cells at the early zebrafish embryo
Scott G Wilcockson et al.
Developmental cell, 58(23), 2802-2818 (2023-09-16)
Extracellular signal-regulated kinase (Erk) signaling dynamics elicit distinct cellular responses in a variety of contexts. The early zebrafish embryo is an ideal model to explore the role of Erk signaling dynamics in vivo, as a gradient of activated diphosphorylated Erk (P-Erk)
Ramon Cesar Botigelli et al.
Frontiers in cell and developmental biology, 10, 938709-938709 (2022-10-04)
Several opportunities for embryo development, stem cell maintenance, cell fate, and differentiation have emerged using induced pluripotent stem cells (iPSCs). However, the difficulty in comparing bovine iPSCs (biPSCs) with embryonic stem cells (ESCs) was a challenge for many years. Here

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