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Merck
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Documenti

PZ0018

Sigma-Aldrich

Bazedoxifene acetate

≥98% (HPLC)

Sinonimo/i:

1-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate, TSE-424, WAY-140424, WAY-TSE-424

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About This Item

Formula empirica (notazione di Hill):
C30H34N2O3 · C2H4O2
Numero CAS:
198481-33-3
Peso molecolare:
530.65
Codice UNSPSC:
51111800
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to beige

Solubilità

DMSO: 15 mg/mL, clear

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

InChI

1S/C30H34N2O3.C2H4O2/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31;1-2(3)4/h6-15,20,33-34H,2-5,16-19,21H2,1H3;1H3,(H,3,4)
OMZAMQFQZMUNTP-UHFFFAOYSA-N

Applicazioni

Bazedoxifene acetate has been used to study its efficacy in inhibiting the interleukin-6 (IL-6)/IL-6R/glycoprotein 130 pathway and its effects on medulloblastoma cells.

Azioni biochim/fisiol

Bazedoxifene is a third generation nonsteroidal selective estrogen receptor modulator (SERM), used clinically to treat postmenopausal osteoporosis. Bazedoxifene binds to estrogen receptor-α with IC50 = 26 nM, similar to that of raloxifene, but lower affinity than 17-β estradiol. Bazedoxifene did not stimulate proliferation of MCF-7 cells, instead inhibited 17β -estradiol-induced proliferation with IC50 = 0.19 nM, exhibiting a desirable profile of agonist/antagonist activity.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Fulvestrant >98% (HPLC)

Sigma-Aldrich

I4409

Fulvestrant

(Z) -4-idrossitamoxifene ≥98% Z isomer

Sigma-Aldrich

H7904

(Z) -4-idrossitamoxifene

β-Estradiol ≥98%

Sigma-Aldrich

E8875

β-Estradiol

Blanca D López-Ayllón et al.
Frontiers in immunology, 14, 1220306-1220306 (2023-08-07)
SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins encoded in its genome. Their roles during infection are still not completely understood. In this study, transcriptomics analysis revealed that both WNT5A and IL11 were significantly up-regulated in A549
Blocking interleukin-6 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity of human medulloblastoma cells
Xiang Chen
International Journal of Oncology (2018)
Yanan Chen et al.
eLife, 10 (2021-03-24)
The inflammatory environment of demyelinated lesions in multiple sclerosis (MS) patients contributes to remyelination failure. Inflammation activates a cytoprotective pathway, the integrated stress response (ISR), but it remains unclear whether enhancing the ISR can improve remyelination in an inflammatory environment.
Adam T Szafran et al.
iScience, 25(10), 105200-105200 (2022-10-15)
The United States Environmental Protection Agency (EPA) has been pursuing new high throughput in vitro assays to characterize endocrine disrupting chemicals (EDCs) that interact with estrogen receptor signaling. We characterize two new PRL-HeLa cell models expressing either inducible C-terminal (iGFP-ER) or
Xiang Chen et al.
International journal of oncology, 52(2), 571-578 (2017-12-06)
Elevated levels of the pro-inflammatory cytokine interleukin-6 (IL‑6) have tumor-promoting activity and are associated with poor survival outcomes in many cancers. Additionally, the IL‑6/GP130/STAT3 axis has been widely studied due to its pivotal role in tumor development and maintenance in
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