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P0184

Sigma-Aldrich

Pseudomonas exotoxin A from Pseudomonas aeruginosa

lyophilized powder

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About This Item

Numero CAS:
91262-95-2
Numero MDL:
MFCD00132134
Codice UNSPSC:
12352200
NACRES:
NA.77

Forma fisica

lyophilized powder

Livello qualitativo

200

Composizione

Protein, ~30% E1%/280

Temperatura di conservazione

2-8°C

Descrizione generale

Pseudomonas exotoxin A is secreted by Pseudomonas aeruginosa. It is a member of the family mono-ADP-ribosyltransferases.

Azioni biochim/fisiol

Pseudomonas exotoxin A functions as an anticancer agent.
It catalyses the transfer of ADP-ribose moiety of NAD+ to the histidine imidazole ring of diphthamide.
Shown to be toxic to animals and to cell lines, and to inhibit protein synthesis via ADP ribosylation of elongation factor 2.

Confezionamento

Package size based on protein content.

Stato fisico

Lyophilized powder containing Tris buffer, EDTA, NaCl and lactose

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301 + H311 + H331

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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USP

USP

1235503

Endotoxin

Anti-Goat IgG (whole molecule)–Peroxidase antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

A5420

Anti-Goat IgG (whole molecule)–Peroxidase antibody produced in rabbit

MOPS ≥99.5% (titration)

Sigma-Aldrich

M1254

MOPS

Ponceau S BioReagent, suitable for electrophoresis

Sigma-Aldrich

P3504

Ponceau S

Mutations in the Elongation Factor 2 Gene Which Confer Resistance to Diphtheria Toxin and Pseudomonas Exotoxin A GENETIC AND BIOCHEMICAL ANALYSES
Foley BT, et al.
The Journal of Biological Chemistry, 270(39), 23218-23225 (1995)
B H Iglewski et al.
Infection and immunity, 15(1), 138-144 (1977-01-01)
Previous studies showed that Pseudomonas aeruginosa exotoxin A (PA toxin) catalyzes nicotinamide adenine dinucleotide (NAD)-dependent inhibition of protein synthesis in a rabbit reticulocyte lysate and transfer of radioactivity from [14C]adenine-labeled NAD to a protein having the same molecular weight as
Pseudomonas exotoxin A: from virulence factor to anti-cancer agent
Wolf P and Elsasser-Beile U
International Journal of Medical Microbiology : IJMM, 299(3), 161-176 (2009)
Preparation of Pseudomonas exotoxin A.
K J Kozak et al.
Methods in enzymology, 165, 147-152 (1988-01-01)
J L Middlebrook et al.
Canadian journal of microbiology, 23(2), 183-189 (1977-02-01)
The sensitivities of 21 mammalian cell lines to the exotoxins of Pseudomonas aeruginosa and Corynebacterium diphtheriae were measured. Each line exhibited 1-4 log differences in sensitivities to the two toxins. No species-specific sensitivities were noted for Pseudomonas exotoxin while diphtheria
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