This product is analyzed for solubility in DMSO at ≥ 10.0 mg/ mL on a lot to lot basis. The MML references the solubility in mg/mL.
O9890
5Z-7-Oxozeaenol
≥98% (HPLC), powder, TAK1 inhibitor
Sinonimo/i:
C 292, F 152, FR148083, L 783279, LL-Z1640-2
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1 MG
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About This Item
Formula empirica (notazione di Hill):
C19H22O7
Numero CAS:
Peso molecolare:
362.37
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
5Z-7-Oxozeaenol, ≥98% (HPLC)
Saggio
≥98% (HPLC)
Stato
powder
Colore
white to off-white
Solubilità
DMSO: >10 mg/mL
Temperatura di conservazione
2-8°C
Stringa SMILE
COc1cc(O)c2C(=O)O[C@@H](C)CC=CC(=O)[C@@H](O)[C@@H](O)C\C=C\c2c1
InChI
1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
NEQZWEXWOFPKOT-BYRRXHGESA-N
Applicazioni
5Z-7-Oxozeaenol has been used:
- as transforming growth factor β-activated kinase 1 (TAK1) inhibitor to treat human colon cancer cells[1]
- as TAK1-specific inhibitor to provide intraperitoneal injection to mice for aortic banding[2]
- as TAK1 inhibitor to treat cells for luciferase reporter assay[3]
- to test growth and differentiation factor 2 (GDF2)-mediated anoikis[4]
Azioni biochim/fisiol
5Z-7-oxozeaenol is a potent ATP-competitive irreversible inhibitor of ERK2 (IC50 = 80 nM), TAK1 (MEKK7), MKK7, and MEK1, which all contain a common cysteine residue in the ATP-binding site. 5Z-7-oxozeaenol has no activity against other MAP kinases. 5Z-7-oxozeaenol is also anti-inflammatory.
The anti-inflammatory effects of 5Z-7-oxozeaenol may affect cardiac hypertrophy.[2]
Caratteristiche e vantaggi
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the MAPKKKs and MAPKs pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Discover Bioactive Small Molecules for Kinase Phosphatase Biology
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En el CoA de este producto (5Z-7-Oxozeaenol) la concentración en DMSO aparece expresada en MML. ¿Podrían aclararme qué significan esas unidades?¿Masa x vol?¿mmol/L?Porque no consigo encontrar ninguna referencia de concentraciones expresadas en MML.Gracias
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