O4126

Oxaloacetic acid

≥97% (HPLC)

• Sinonimo/i: 2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxobutanedioic acid
• Formula condensata: HOOCCH₂COCOOH
• Numero CAS: 328-42-7
• Peso molecolare: 132.07
• Beilstein: 1705475
• Numero CE: 206-329-8
• Numero MDL: MFCD00002592
• Codice UNSPSC: 12352204
• ID PubChem: 24897993
• NACRES: NA.32

Proprietà

• Livello qualitativo: 200
• Saggio: ≥97% (HPLC)
• Stato: powder
• Solubilità: H₂O: 100 mg/mL, clear to slightly hazy, colorless to light yellow
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC(=O)CC(=O)C(O)=O
• InChI: 1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9); KHPXUQMNIQBQEV-UHFFFAOYSA-N

Descrizione

Descrizione generale

Oxaloacetic acid is a dicarboxylic acid. It is an intermediate in the citric acid cycle. It is highly soluble in water and is present ubiquitously. It is produced in the mitochondria by the action of pyruvate carboxylase on pyruvate. Breakdown products of oxaloacetate includes malate, pyruvate and aspartic acid.

Applicazioni

Oxaloacetic acid has been used as a substrate for measuring citrate synthase activity in cybrids and neuroblastoma cells. It has also been used for measuring malate dehydrogenase reactivation.

Azioni biochim/fisiol

Oxaloacetic acid being an intermediate in the tri carboxylic cycle is central to metabolism. It is part of gluconeogenesis pathway. Mutation in pyruvate carboxylase leads to decreased production of oxaloacetate. It inhibits succinate dehydrogenase and is a key regulator of mitochondrial metabolism.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H319
• Consigli di prudenza: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classi di pericolo: Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges