N2288
Nefiracetam
solid
Sinonimo/i:
(2-(2-oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide), DM-9384
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50 MG
190,00 €
250 MG
699,00 €
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Cambia visualizzazione
50 MG
190,00 €
250 MG
699,00 €
About This Item
Formula empirica (notazione di Hill):
C14H18N2O2
Numero CAS:
Peso molecolare:
246.30
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Stato
solid
Colore
white to off-white
Solubilità
DMSO: >5 mg/mL
Stringa SMILE
Cc1cccc(C)c1NC(=O)CN2CCCC2=O
InChI
1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
NGHTXZCKLWZPGK-UHFFFAOYSA-N
Azioni biochim/fisiol
Nefiracetam (NEF) is a pyrrolidonetype nootropic agent with various pharmacologic as well as cognition enhancing effects. In amygdala-kindled seizures, nefiracetam inhibits both electroencephalographic and behavioral seizures. NEF has a distinct anticonvulsant spectrum.
Novel pyrrolidonetype nootropic (condition enhancing) agent with anticonvulsant spectrum.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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Ricardo E Jorge et al.
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 55(6), 350-354 (2010-06-15)
We will review the available evidence on the frequency, clinical correlates, mechanism, and treatment of apathy following stroke. We have explored relevant databases (that is, PubMed, MEDLINE, and PsycINFO) using the following key words and their combinations: apathy, motivation, abulia
Shigeki Moriguchi et al.
Journal of neurochemistry, 106(3), 1092-1103 (2008-05-01)
Nefiracetam is a pyrrolidine-related nootropic drug exhibiting various pharmacological actions such as cognitive-enhancing effect. We previously showed that nefiracetam potentiates NMDA-induced currents in cultured rat cortical neurons. To address questions whether nefiracetam affects NMDA receptor-dependent synaptic plasticity in the hippocampus
Robert G Robinson et al.
The Journal of neuropsychiatry and clinical neurosciences, 20(2), 178-184 (2008-05-03)
In preliminary trials, nefiracetam, a gamma aminobutyric compound, enhanced blood flow and improved mood following stroke. Within 3 months following stroke with major depression, 159 patients were enrolled in a double-blind trial of nefiracetam or placebo. Repeated measures analysis of
Yoshimi Tsuchiya et al.
Toxicologic pathology, 33(5), 561-569 (2005-08-18)
To ascertain the early pathophysiological features in canine renal papillary necrosis (RPN) caused by the neurotransmission enhancer nefiracetam, male beagle dogs were orally administered nefiracetam at 300 mg/kg/day for 4 to 7 weeks in comparison with ibuprofen, a non-steroidal anti-inflammatory
Yijin Yan et al.
Behavioural brain research, 173(1), 39-46 (2006-07-22)
Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam
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