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B2680

Sigma-Aldrich

Bone Morphogenetic Protein 4 human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Sinonimo/i:

BMP-4

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About This Item

Numero MDL:
MFCD01867024
Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human

Livello qualitativo

200

Ricombinante

expressed in NSO cells

Saggio

>95% (SDS-PAGE)

Forma fisica

lyophilized powder

Potenza

10-30 ng/mL ED50

PM

monomer calculated mol wt 13 kDa
 ~22 kDa by SDS-PAGE

Confezionamento

pkg of 10 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

tecniche

cell culture | mammalian: suitable

Impurezze

<1 EU/mg Endotoxin level (LAL test)

N° accesso UniProt

P12644

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... BMP4(652)

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Categorie correlate

Azioni biochim/fisiol

Cellular responses to BMP-4 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMPs stimulate angiogenesis by inducing the production of VEGF A by osteoblasts. Mature human and mouse BMP-4 demonstrates 98% and 100% homology, respectively, to mature rat BMP-4.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of cytokine.

Risultati analitici

The biological activity is measured by its ability to induce alkaline phosphatase production by C2C12 myoblasts.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which are members of the transforming growth factor-beta (TGF-beta) superfamily. Activities of BMPs are extracellularly regulated by BMP-binding proteins, Noggin and Chordin. BMPs bind to two different types of serine-threonine kinase receptors, type
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During bone formation and fracture healing there is a cross-talk between endothelial cells and osteoblasts. We previously showed that vascular endothelial growth factor A (VEGF-A) might be an important factor in this cross-talk, as osteoblast-like cells produce this angiogenic factor
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Chordin-Like 1 (CHRDL1) mutations cause non-syndromic X-linked megalocornea (XMC) characterized by enlarged anterior eye segments. Mosaic corneal degeneration, presenile cataract and secondary glaucoma are associated with XMC. Beside that CHRDL1 encodes Ventroptin, a secreted bone morphogenetic protein (BMP) antagonist, the
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