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Merck
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I6410

Sigma-Aldrich

ISCK03

≥98% (HPLC), solid

Sinonimo/i:

Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl], [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide

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About This Item

Formula empirica (notazione di Hill):
C19H21N3O2S
Numero CAS:
945526-43-2
Peso molecolare:
355.45
Numero MDL:
MFCD12031591
Codice UNSPSC:
12352200
ID PubChem:
329815393
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

yellow

Solubilità

DMSO: ≥20 mg/mL
H2O: insoluble

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)-n3ccnc3

InChI

1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3
XQABBHBFHWHMKF-UHFFFAOYSA-N

Azioni biochim/fisiol

ISCK03 inhibits in vitro phosphorylation of c-Kit in a dose dependent manner. ISCK03 inhibits SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells. Complete inhibition was observed with 1 and 5 μM ISCK03.

Caratteristiche e vantaggi

This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Yuan Ma et al.
Cell cycle (Georgetown, Tex.), 19(16), 2074-2080 (2020-07-14)
Neurogenic bladder (NB) is a type of double renal dysfunction caused by nerve lesions. The interstitial cells of Cajal (ICC) damage are involved in bladder dysfunction. The aim of this study is to investigate the effect of stem cell factor
Hiroko Morimoto et al.
PloS one, 4(11), e7909-e7909 (2009-11-26)
Spermatogonial stem cells (SSCs) continuously undergo self-renewal division to support spermatogenesis. SSCs are thought to have a fixed phenotype, and development of a germ cell transplantation technique facilitated their characterization and prospective isolation in a deterministic manner; however, our in
Jin Man Kim et al.
Development (Cambridge, England), 148(6) (2021-03-05)
The actomyosin complex plays crucial roles in various life processes by balancing the forces generated by cellular components. In addition to its physical function, the actomyosin complex participates in mechanotransduction. However, the exact role of actomyosin contractility in force transmission
Genevra Kuziel et al.
Cancers, 12(8) (2020-08-01)
Obesity is correlated with breast tumor desmoplasia, leading to diminished chemotherapy response and disease-free survival. Obesity causes chronic, macrophage-driven inflammation within breast tissue, initiated by chemokine ligand 2 (CCL2) signaling from adipose stromal cells. To understand how CCL2-induced inflammation alters
Cheong-Yong Yun et al.
Theranostics, 10(1), 340-352 (2020-01-07)
Rationale: Microphthalmia-associated transcription factor M (MITF-M) plays important roles in the pigment production, differentiation and survival of melanocytes. Stem cell factor (SCF) and its receptor KIT stimulate MITF-M activity via phosphorylation at the post-translation level. However, the phosphorylation shortens half-life
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