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GW22654

Sigma-Aldrich

Anti-Talin-2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

chicken

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

rat, human, mouse

tecniche

western blot: suitable

N° accesso NCBI

NP_055874.1

N° accesso UniProt

Q9Y4G6

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... TLN2(83660)

Immunogeno

Immunogen Sequence: GI # 22035665, sequence 1750-1950
Recombinant talin 2

Applicazioni

Anti-Talin-2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

Talin 2 is a protein encoded by the TLN2 gene in humans and belongs to the talin protein family. It plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. Talin 2 also plays a crutial role in cell adhesion and recycling of synaptic vesicles. It may help in serving as a link between integrins and the sarcomeric cytoskeletonin stable adhesion complexes in mature striated muscle.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

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Lei Qi et al.
Journal of cell science, 129(19), 3661-3674 (2016-10-04)
Talin binds to β-integrin tails to activate integrins, regulating cell migration, invasion and metastasis. There are two talin genes, TLN1 and TLN2, encoding talin1 and talin2, respectively. Talin1 regulates focal adhesion dynamics, cell migration and invasion, whereas the biological function
Zheng Xiao et al.
Clinical biochemistry, 43(13-14), 1129-1132 (2010-07-14)
Talin 2 plays an important role in cell adhesion and recycling of synaptic vesicles. To explore the possible role of talin 2 in epilepsy, we designed current study to quantitatively evaluate the changes in talin 2 levels in different epilepsy
Melissa A Senetar et al.
Cell motility and the cytoskeleton, 64(3), 157-173 (2006-12-22)
The cytoskeletal protein talin serves as an essential link between integrins and the actin cytoskeleton in several similar, but functionally distinct, adhesion complexes, including focal adhesions, costameres, and intercalated disks. Vertebrates contain two talin genes, TLN1 and TLN2, but the

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