F7930
FGFR3 (397-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinonimo/i:
Eph receptor tyrosine kinase, growth hormone receptor, ACH, CD333, CEK2, HSFGFR3EX, JTK4
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10 μG
532,00 €
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Cambia visualizzazione
10 μG
532,00 €
About This Item
Codice UNSPSC:
51111800
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in baculovirus infected Sf9 cells
Nome Commerciale
PRECISIO® Kinase
Saggio
≥70% (SDS-PAGE)
Stato
buffered aqueous glycerol solution
Attività specifica
95-129 nmol/min·mg
PM
~73 kDa
Confezionamento
pkg of 10 μg
tecniche
cell based assay: suitable
Solubilità
water: soluble
N° accesso ID proteina
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... FGFR3(2261)
Descrizione generale
Research area: Cancer
FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.[1]FGFR3 has a strong affinity for canonical FGF ligands.[2]
FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.[1]FGFR3 has a strong affinity for canonical FGF ligands.[2]
Azioni biochim/fisiol
FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis and angiogenesis. [3] This gene is either mutated or up-regulated in multiple myeloma, cervical carcinoma [3] and nonmuscle-invasive urothelial carcinoma (UC) of the bladder.[4]Apart from this, certain mutations in FGFR3 are also known to be linked with skeletal disorders such as various forms of dwarfism. [3] FGFR3 also plays hepatoprotective function during liver damage. [5]
Stato fisico
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Note legali
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Corine G M L'Hôte et al.
Experimental cell research, 304(2), 417-431 (2005-03-08)
FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a negative regulatory effect on long bone growth. Fgfr3 knockout mice display longer bones and, accordingly, most germline-activating mutations in man are associated with dwarfism.
Hiroko Tamagaki et al.
Biochemistry, 53(30), 5000-5007 (2014-07-11)
Activation of the protein tyrosine kinase receptors requires the coupling of ligand binding to a change in both the proximity and orientation of the single transmembrane (TM) helices of receptor monomers to allow transphosphorylation of the receptor kinase domain. We
FGFR3 biology and skeletal disease
Jyoti Narayana and William A Horton
Connective tissue research, 56(6), 427-433 (2015)
Elizabeth A Guancial et al.
Cancer medicine, 3(4), 835-844 (2014-05-23)
While fibroblast growth factor receptor 3 (FGFR3) is frequently mutated or overexpressed in nonmuscle-invasive urothelial carcinoma (UC), the prevalence of FGFR3 protein expression and mutation remains unknown in muscle-invasive disease. FGFR3 protein and mRNA expression, mutational status, and copy number
Lin Chen et al.
Frontiers in bioscience : a journal and virtual library, 10, 1961-1976 (2005-03-17)
Fibroblast growth factor receptors (FGFRs) exist as a gene family of 4 membrane bound receptor tyrosine kinases (FGFR1-4) that mediate signals of at least 22 fibroblast growth factors (FGF1-22). FGFs/FGFRs play important roles in multiple biological processes, including mesoderm induction
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