E8399
Eotaxin-3 human
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Sinonimo/i:
CCL26, SCYA26
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25 μG
332,00 €
332,00 €
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Cambia visualizzazione
25 μG
332,00 €
About This Item
332,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in E. coli
Saggio
>97% (SDS-PAGE)
Stato
lyophilized powder
Potenza
0.25-1.0 mg
PM
~8.2 kDa
Confezionamento
pkg of 25 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
tecniche
cell culture | mammalian: suitable
Impurezze
endotoxin, tested
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... CCL26(10344)
Descrizione generale
Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3.[1] This gene is localized to human chromosome 7q11.2, which codes for a protein of 71 amino acids.[2] It belongs to the small inducible cytokine subfamily A [3], which also includes eotaxin and eotaxin-2.[4]
Azioni biochim/fisiol
Also known as CCL26 or SCYA26; a human CC chemokine and a functional ligand for CC chemokine receptor 3; mature recombinant human eotaxin-3 demonstrates chemotactic activity for eosinophils.
Eotaxin-3 is a potent attractant of eosinophils, and might be responsible for the accumulation of eosinophils in atopic diseases.[2] As it is involved in the recruitment of eosinophils in inflammatory diseases, it, along with its receptor, might have potential as therapeutic target in inflammatory disorders, such as asthma.[1] Demethylation results in increased expression of this gene, which in turn influences allergic reactions.[5] This gene is overexpressed in bullous pemphigoid (BP), which results in the accumulation of eosinophils in skin lesions, thus, contributing to the pathogenesis of BP.[4] Its expression is also elevated in the active lesions of patients with ulcerative colitis (UC) and Crohn′s disease (CD). Thus, it might play a role in the pathogenesis of UC, where its major source is colonic myofibroblasts.[6]
Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3. Mature recombinant human eotaxin-3 has a molecular mass of approximately 8.2 kDa and demonstrates chemotactic activity for eosinophils.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.
Risultati analitici
The biological activity is measured by its ability to induce chemotaxis of rat Y3 cells stably expressing hCCR3.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Inhalation - Eye Irrit. 2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Eunjin Lim et al.
Journal of immunology (Baltimore, Md. : 1950), 192(1), 466-474 (2013-12-11)
DNA demethylation has been primarily studied in the context of development biology, cell fate, and cancer, with less attention on inflammation. In this article, we investigate the association between DNA methylation and production of the chemoattractant cytokine eotaxin-3 in the
A Shinkai et al.
Journal of immunology (Baltimore, Md. : 1950), 163(3), 1602-1610 (1999-07-22)
IL-4 has been shown to be involved in the accumulation of leukocytes, especially eosinophils, at sites of inflammation by acting on vascular endothelial cells. To identify novel molecules involved in the IL-4-dependent eosinophil extravasation, cDNA prepared from HUVEC stimulated with
K Takahashi et al.
Clinical and experimental immunology, 173(2), 323-331 (2013-04-24)
Eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3). In this study, we investigated eotaxin-3/CC chemokine ligand 26 (CCL26) expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD), and
C Günther et al.
Clinical and experimental immunology, 166(2), 145-153 (2011-10-12)
Eosinophils contribute to the pathogenesis of bullous pemphigoid (BP) by secretion of proinflammatory cytokines and proteases. Trafficking of eosinophils into tissue in animal models and asthma depends on interleukin-5 and a family of chemokines named eotaxins, comprising CCL11, CCL24 and
R F Guo et al.
Genomics, 58(3), 313-317 (1999-06-22)
By searching the Expressed Sequence Tag database, a full-length cDNA for a novel human CC chemokine was cloned. This cDNA encoded a 94-amino-acid protein with a putative signal peptide of 26 amino acids. The deduced mature protein had the four
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