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D5446

Sigma-Aldrich

7,8-Dihydroxyflavone hydrate

≥98% (HPLC)

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10 MG
80,60 €
50 MG
323,00 €

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10 MG
80,60 €
50 MG
323,00 €

About This Item

Formula empirica (notazione di Hill):
C15H10O4 · xH2O
Numero CAS:
38183-03-8
Peso molecolare:
254.24 (anhydrous basis)
Numero CE:
253-812-4
Numero MDL:
MFCD00006836
Codice UNSPSC:
12352200
ID PubChem:
329798806
NACRES:
NA.77

80,60 €

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Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

solid

Condizioni di stoccaggio

desiccated

Solubilità

DMSO: 24 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3

InChI

1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
COCYGNDCWFKTMF-UHFFFAOYSA-N

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Applicazioni

7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice[1][2] and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).[3]

Azioni biochim/fisiol

7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension.[4] 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.[5]
7,8-Dihydroxyflavone is a selective TrkB receptor agonist
7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
0000142759
0000123649
0000123650
0000075667
0000075668

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Xiaojuan Liu et al.
Molecules (Basel, Switzerland), 25(4) (2020-02-23)
O-methylation of flavonoids is an important modification reaction that occurs in plants. O-methylation contributes to the structural diversity of flavonoids, which have several biological and pharmacological functions. In this study, an O-methyltransferase gene (CrOMT2) was isolated from the fruit peel
Vasorelaxing and antihypertensive effects of 7, 8-dihydroxyflavone
Huai R
American Journal of Hypertension, 27(5), 750-760 (2013)
Maria N Schultz et al.
Learning & memory (Cold Spring Harbor, N.Y.), 27(9), 346-354 (2020-08-21)
Angelman syndrome is a rare neurodevelopmental disorder caused by a mutation in the maternal allele of the gene Ube3a The primary symptoms of Angelman syndrome are severe cognitive deficits, impaired motor functions, and speech disabilities. Analogous phenotypes have been detected
Oligodendrocytes regulate presynaptic properties and neurotransmission through BDNF signaling in the mouse brainstem
Jang M, et al.
eLife, 8, e42156-e42156 (2019)
Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation
Kang MS, et al.
The Journal of Experimental Medicine, 214(10), 2947-2966 (2017)
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Domande

  1. What are the recommended storage conditions for D5446 after reconstitution?

    1 risposta

    1. Although there is no datasheet available for product D5446, there is information available for a product sharing the same CAS number from a different division. Below is the information found for product 506300 (7,8 Dihydroxyflavone):

      - Solubility: DMSO (100 mg/ml)
      - Storage: Protect from light, +2°C to +8°C
      - Do Not Freeze: Ok to freeze
      - Special Instructions: Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

      This information will also apply for product D5446. There are additional notes stating the product is packaged under inert gas. Therefore, if storing, it would be best to leave no air space in the storage container if possible. If that is not possible, it would be best to store under either dry nitrogen or argon.

      Utile?

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