A7687

Aloe-emodin

≥95% (HPLC)

• Sinonimo/i: 1,8-Dihydroxy 3-hydroxymethylanthraquinone, 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone, 3-Hydroxymethylchrysazine, Rhabarberone
• Formula empirica (notazione di Hill): C₁₅H₁₀O₅
• Numero CAS: 481-72-1
• Peso molecolare: 270.24
• UNSPSC Code: 12352205
• NACRES: NA.79
• PubChem Substance ID: 24891267
• EC Number: 207-571-7
• Beilstein/REAXYS Number: 2059062
• MDL number: MFCD00017373

Proprietà

• biological source: plant root (Rheum palmatum)
• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: powder
• technique(s): HPLC: suitable
• color: yellow to brown
• storage temp.: 2-8°C
• SMILES string: OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
• InChI: 1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
• InChI key: YDQWDHRMZQUTBA-UHFFFAOYSA-N

Descrizione

General description

Aloe-emodin is a hydroxyanthraquinone found naturally in aloe plants.

Application

Aloe-emodin has been used as a standard in high performance liquid chromatography (HPLC) for separation and identification of phenolic compounds in Aloe arborescens Miller var. natalensis Berger (Kidachi aloe).

Biochem/physiol Actions

Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.

Aloe-emodin exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves