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A5330

Sigma-Aldrich

N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester

≥99% (TLC), powder

Sinonimo/i:

L-732,138

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About This Item

Formula empirica (notazione di Hill):
C22H18F6N2O3
Numero CAS:
148451-96-1
Peso molecolare:
472.38
Numero MDL:
MFCD00237267
Codice UNSPSC:
12352200
ID PubChem:
24277690

Saggio

≥99% (TLC)

Stato

powder

Punto di fusione

147-148 °C (lit.)

Temperatura di conservazione

−20°C

Stringa SMILE

CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc3cc(cc(c3)C(F)(F)F)C(F)(F)F

InChI

1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1
BYYQYXVAWXAYQC-IBGZPJMESA-N

Informazioni sul gene

human ... TACR1(6869)

Azioni biochim/fisiol

Competitive substance P receptor antagonist.
Competitive substance P receptor antagonist. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors; and approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. The IC50 for the human NK-1 receptor expressed in CHO cells is approximately 2 nM.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
026K1309
055K1520
090K1374
030K1778
025H0214

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Ammar Boudaka et al.
European journal of pharmacology, 556(1-3), 157-165 (2006-12-13)
Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, has been suggested to mediate the inhibitory effect of capsaicin on vagally mediated striated muscle contractions in the
Takenori Onaga et al.
Regulatory peptides, 173(1-3), 64-73 (2011-10-06)
The present study investigated a role of tachykinins (TK) and neurokinin (NK) receptors (NK-R) in the non-cholinergic regulation of omasal contractions in sheep. Semiquantitative reverse transcription (RT)-PCR revealed that both preprotachykinin (PPT)-A and PPT-B mRNA were distributed in the omasal
Ming-Ming Zhang et al.
PloS one, 8(3), e59234-e59234 (2013-04-05)
Substance P (SP) and its receptor, the neurokinin 1 receptor (NK1R), play important roles in transmitting and regulating somatosensory nociceptive information. However, their roles in visceral nociceptive transmission and regulation remain to be elucidated. In the previous study, moderate SP
Miguel Muñoz et al.
Investigational new drugs, 26(2), 111-118 (2007-10-02)
It has been demonstrated that substance P (SP) induces cell proliferation and neurokinin-1 (NK-1) receptor antagonists inhibit growth in several human cancer cell lines, but it is currently unknown whether such actions are exerted on human laryngeal carcinoma cell line
Miguel Muñoz et al.
Peptides, 38(2), 318-325 (2012-10-03)
The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development
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