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Y0000664

Methotrexate impurity E

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

4-{[(2,4-Diaminopteridin-6-yl)methyl]methylamino}benzoic acid

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10 MG
133,00 €

133,00 €


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Cambia visualizzazione
10 MG
133,00 €

About This Item

Formula empirica (notazione di Hill):
C15H14N7O2
Numero CAS:
Peso molecolare:
324.32
Codice UNSPSC:
41116107
NACRES:
NA.24

133,00 €


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Grado

pharmaceutical primary standard

Famiglia di API

methotrexate

Produttore/marchio commerciale

EDQM

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

N(Cc2nc3c(nc(nc3N)N)nc2)(C)c1ccc(cc1)C(=O)O

InChI

1S/C15H15N7O2/c1-22(10-4-2-8(3-5-10)14(23)24)7-9-6-18-13-11(19-9)12(16)20-15(17)21-13/h2-6H,7H2,1H3,(H,23,24)(H4,16,17,18,20,21)
LWCXZSDKANNOAR-UHFFFAOYSA-N

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Methotrexate impurity E EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Pittogrammi

Skull and crossbonesHealth hazard

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 3 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

Lot/Batch Number

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B C Widemann et al.
The Journal of pharmacology and experimental therapeutics, 294(3), 894-901 (2000-08-17)
The novel methotrexate (MTX) rescue agent carboxypeptidase-G(2) (CPDG(2)) converts >98% of plasma MTX to 2, 4-diamino-N(10)-methylpteroic acid (DAMPA) and glutamate in patients with MTX-induced renal failure and delayed MTX excretion. DAMPA is eliminated more rapidly than MTX in these patients
Masanobu Uchiyama et al.
Biomedical chromatography : BMC, 26(1), 76-80 (2011-03-26)
A simple and sensitive HPLC method has been developed for the determination of methotrexate (MTX) and its major metabolites, 7-hydroxymethotrexate (7-OH-MTX) and 2,4-diamino-N(10-) methylpteroic acid (DAMPA), in human plasma. After deproteinization of the plasma with 5% aqueous acetonitrile solution containing
D A Cairnes et al.
Therapeutic drug monitoring, 5(3), 363-366 (1983-01-01)
Simple and convenient preparations of two metabolites of the antineoplastic drug methotrexate (MTX) are described. MTX is incubated in a Tris-HCl rabbit liver homogenate to produce 7-hydroxymethotrexate. Filtration, lyophilization, and recrystallization from water gives a chromatographically pure product. Analytical amounts
Rapid quantitation of methotrexate and its metabolites in human serum, urine and bile, using solid-phase extraction and high-performance liquid chromatography.
B Nuernberg et al.
Journal of chromatography, 487(2), 476-482 (1989-02-24)
H N Alkaysi et al.
Therapeutic drug monitoring, 12(2), 191-194 (1990-03-01)
A procedure for the determination of methotrexate in human plasma is reported. The analysis involved extraction of methotrexate as an ion pair in ethyl acetate. Reconstituted residue was analyzed using reverse phase C-18 column and a mobile phase consisting of

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