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1414003

USP

Methotrexate

Name: Methotrexate
Brand: USP
Price: 405 EUR

United States Pharmacopeia (USP) Reference Standard

Sinonimo/i:

(+)-Amethopterin, 4-Amino-10-methylfolic acid, 4-Amino-N¹⁰-methylpteroyl-L-glutamic acid, Antifolan, MTX, Methylaminopterin

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A voi/SKU	Disponibilità	Prezzo
500 mg	Per informazioni sulla disponibilità, contatta il Servizio Clienti.	405,00 €

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₀H₂₂N₈O₅

Numero CAS:

59-05-2

Peso molecolare:

454.44

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329750410

MDL number:

MFCD00064370

Beilstein/REAXYS Number:

70669

405,00 €

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Proprietà

grade

pharmaceutical primary standard

agency

USP

API family

methotrexate

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1

InChI key

FBOZXECLQNJBKD-ZDUSSCGKSA-N

Gene Information

human ... DHFR(1719)

Descrizione

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methotrexate USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Methotrexate Injection
Methotrexate Tablets
Methotrexate for Injection

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1 of 1

Questo articolo	M1000000	Y0001668	PHR1396
USP 1414003 Methotrexate	M1000000 Methotrexate	Y0001668 Methotrexate for system suitability	Supelco PHR1396 Methotrexate
manufacturer/tradename USP	manufacturer/tradename EDQM	manufacturer/tradename EDQM	manufacturer/tradename -
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
API family methotrexate	API family methotrexate	API family methotrexate	API family methotrexate
storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C	storage temp. 2-8°C

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Explore all of our products under Methotrexate

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H341,H360D,H372

pcodes

P202 - P260 - P264 - P280 - P301 + P310 - P405

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2 - Repr. 1B - STOT RE 1

target_organs

Liver,Bone marrow

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Domande

3 anni fa

hello, Can I use methotrexate 1414003 in cell culture? If yes, what should I use to disolve?

1 risposta
1. Technical Support
  
  3 anni fa
  
  Product number 1414003 is a United States Pharmacopeia (USP) reference standard used in analytical method validation, system suitability testing, assays, and quality control checks. It has not been validated for use in cell culture applications.
  Product number M8407 is a methotrexate hydrate that has been tested for cell culture: https://www.sigmaaldrich.com/US/en/product/sigma/m8407
  Methotrexate is insoluble in water, ethanol, chloroform, and ether. It is, however, soluble in solutions of mineral acids and in dilute solutions of alkali hydroxides and carbonates. (1) Methotrexate is unstable in basic solution. (2) For cell culture work, a stock solution of methotrexate is prepared using a minimum amount of 1 M NaOH and then diluted with saline or medium. The diluted stock remains active at 4–8 °C for about a week or at –20 °C for about a month.
  References
  1. Martindale: the Extra Pharmacopoeia, 29th ed., p. 636 (1989).
  2. Merck Index, 12th ed., #6065 (1996).
  
  Utile?

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