PHR1782

Hydroxychloroquine Sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinonimo/i: Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
• Formula empirica (notazione di Hill): C₁₈H₂₆ClN₃O · H₂SO₄
• Numero CAS: 747-36-4
• Peso molecolare: 433.95
• Numero CE: 212-019-3
• Numero MDL: MFCD00078203
• Codice UNSPSC: 41116107
• ID PubChem: 329823611
• NACRES: NA.24

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 300
• Grado: certified reference material; pharmaceutical secondary standard
• agenzia: BP; EP; USP; traceable to BP 1100; traceable to USP 1327000
• Famiglia di API: hydroxychloroquine
• Stato: powder or crystals
• CdA: current certificate can be downloaded
• Confezionamento: pkg of 1 g
• Condizioni di stoccaggio: protect from light
• tecniche: HPLC: suitable; gas chromatography (GC): suitable
• Colore: white to off-white
• pH: 3.5-5.5 (1% in aqueous solution, pH <6.0)
• Punto di fusione: 238-241 °C
• Solubilità: chloroform: practically insoluble; ethanol: practically insoluble; ether: practically insoluble; water: soluble
• applicazioni: pharmaceutical (small molecule)
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-30°C
• Stringa SMILE: OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4); JCBIVZZPXRZKTI-UHFFFAOYSA-N
• Informazioni sul gene: human ... TLR7(51284) , TLR9(54106)

Descrizione

Descrizione generale

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.[1][2][3][4][4][5]
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Applicazioni

Hydroxychloroquine Sulfate can be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations,[2][6][7] and biological samples[4] by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Azioni biochim/fisiol

Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAC0287 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H315,H319
• Consigli di prudenza: P301 + P312 + P330 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable