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Documenti fondamentali

30873

Supelco

Rhein

analytical standard

Sinonimo/i:

4,5-Dihydroxyanthraquinone-2-carboxylic acid, 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, Cassic acid, Chrysazin 3-carboxylic acid, Monorhein, Rheic acid, Rhubarb yellow

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About This Item

Formula empirica (notazione di Hill):
C15H8O6
Numero CAS:
Peso molecolare:
284.22
Beilstein:
2222155
Numero CE:
Numero MDL:
Codice UNSPSC:
85151701
ID PubChem:
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

Saggio

≥95.0% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Impurezze

≤5.0% water

Punto di fusione

≥300 °C (lit.)

applicazioni

food and beverages

Formato

neat

Stringa SMILE

OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI

1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)
FCDLCPWAQCPTKC-UHFFFAOYSA-N

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Descrizione generale

Rhein is an active component of rhubarb (Rheum officinale), a medicinal herb in traditional Chinese medicine (TCM).[1] It is known to exhibit antibacterial and anti-inflammatory activities.[2]

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Rhein may be used as an analytical reference standard for the determination of the analyte in rat plasma[3] and rhubarb roots, dock flowers and senna leaves[4] by column-switching high-performance liquid chromatography and normal-phase high performance liquid chromatography, respectively.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2


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Certificati d'analisi (COA)

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Supelco

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Rhein protects against acetaminophen-induced hepatic and renal toxicity.
Zhao YL, et al.
Food And Chemical Toxicology, 49(8), 1705-1710 (2011)
Determination of anthraquinones in rhubarb roots, dock flowers and senna leaves by normal-phase high performance liquid chromatography.
Djozan DJ and Assadi Y
Talanta, 42(6), 861-865 (1995)
Simultaneous determination of baicalin, rhein and berberine in rat plasma by column-switching high-performance liquid chromatography.
Yi L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 838(1), 50-55 (2006)
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease.
Zhang Q, et al.
Kidney International, 91(1), 144-156 (2017)
Baoen Chen et al.
Journal of the American Chemical Society, 134(43), 17963-17971 (2012-10-11)
The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N(6)-methyladenosine (m(6)A) residues in mRNA in vitro and inside cells. FTO is the first RNA demethylase discovered that also serves a major regulatory function in mammals. Together with

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