8.51200

DOTA-tris(tert-butyl ester)

Novabiochem^®

• Sinonimo/i: DOTA-tris(tert-butyl ester), Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate
• Formula empirica (notazione di Hill): C₂₈H₅₂N₄O₈
• Numero CAS: 137076-54-1
• Peso molecolare: 572.73
• Numero MDL: MFCD02259697
• Codice UNSPSC: 12352108

Proprietà

• Livello qualitativo: 200
• Nome Commerciale: Novabiochem^®
• Stato: powder
• Impiego in reazioni chimiche: reagent type: fluorescent-labelling reagent
• Produttore/marchio commerciale: Novabiochem^®
• Punto di fusione: 88-93 °C
• applicazioni: peptide synthesis
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C28H52N4O8/c1-26(2,3)38-23(35)19-30-12-10-29(18-22(33)34)11-13-31(20-24(36)39-27(4,5)6)15-17-32(16-14-30)21-25(37)40-28(7,8)9/h10-21H2,1-9H3,(H,33,34); RVUXZXMKYMSWOM-UHFFFAOYSA-N

Descrizione

Descrizione generale

The most convenient reagent for the labeling of a peptide with DOTA ^[1]. This reagent has good solubility in DMF and DCM, and its free carboxyl group can be easily activated using uronium or phosphonium coupling reagents, enabling it to be attached to peptide amino groups. Removal of the t-butyl ester groups from the DOTA occurs during the course of the TFA-mediated cleavage reaction. The progress of the reaction should be monitored as the cleavage of these esters is slow, owing to the proximity of the basic ring nitrogens.

Literature references

^[1] L. M. De León-Rodrýguez & Z. Kovacs (2008) Bioconjugate Chem, 19, 391.

Risultati analitici

Colour (visual): white to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (NMR): ≥ 95.0 %
Identity (NMR): passes test
NMR-spectrum: passes test

Note legali

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°C): Not applicable