119120

Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

• Sinonimo/i: Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt, ATP-γ-S, 4Li
• Formula empirica (notazione di Hill): C₁₀H₁₂N₅O₁₂P₃S · 4Li
• Numero CAS: 93839-89-5
• Peso molecolare: 546.98
• Numero MDL: MFCD00077293
• Codice UNSPSC: 12352208
• NACRES: NA.51

Proprietà

• Livello qualitativo: 100
• Saggio: ≥85% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Impurezze: <10% ADP
• Colore: white
• Solubilità: water: 10 mg/mL
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• InChI: 1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1; DWQFDOIBOYDYKH-KWIZKVQNSA-J

Descrizione

Descrizione generale

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases activity of Ca²⁺-activated K⁺ channels. Used as an inhibitor of ATP-dependent enzyme systems.

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases the activity of Ca²⁺-activated K⁺ channels. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

Applicazioni

• Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.: This study explores the role of purinergic receptors and the NOD-like receptor-family protein 3 (NLRP3) inflammasome pathway in cytokine release induced by adenosine triphosphate (ATP) in macrophages. The findings suggest potential therapeutic targets for inflammatory diseases (Gicquel et al., 2014).


• Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries.: The study demonstrates that extracellular ATP enhances flow-induced vasodilation in small mesenteric arteries in rats, indicating a significant role of ATP in vascular function and potential implications for cardiovascular therapies (Liu et al., 2004).

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.

Altre note

Troadec, J.D., et al. 1999. Pflugers Arch. 437, 745.
Chung, S., et al. 1991. Science253, 560.
Litosch, I., and Fain, J.N. 1986. Life Sci. 39, 187.
Chrysogelos, S., et al. 1983. J. Biol. Chem.258, 12624.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable