Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

860660P

Avanti

Sphingosine (d20:1)

Avanti Research™ - A Croda Brand 860660P, powder

Sinonimo/i:

D-erythro-sphingosine (C20 base)

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali

Scegli un formato

5 MG
330,00 €

330,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Richiedi un ordine bulk
Tutte le immagini(1)

Scegli un formato

Cambia visualizzazione
5 MG
330,00 €

About This Item

Formula empirica (notazione di Hill):
C20H41NO2
Numero CAS:
6918-49-6
Peso molecolare:
327.55
Numero MDL:
MFCD08703031
Codice UNSPSC:
12352211
NACRES:
NA.25

330,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Richiedi un ordine bulk

Stato

powder

Confezionamento

pkg of 1 × 5 mg (860660P-5mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 860660P

Tipo di lipide

sphingolipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCCCC

InChI

1S/C20H41NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(21)18-22/h16-17,19-20,22-23H,2-15,18,21H2,1H3/b17-16+/t19-,20+/m0/s1
HTJSZHKGNMXZJN-YIVRLKKSSA-N

Descrizione generale

Sphingosine (d20:1), also known as icosasphingosine, is a synthetic sphingosine with 20 carbon long chain bases (LCB).[1] It is directly produced by the sphingolipid de novo synthesis pathway and not by hydrolysis of complex sphingolipids.[2] In higher animals, it is one of the most abundant sphingoid bases of gangliosides.[3]

Applicazioni

Sphingosine (d20:1) has been used as a reference substance in liquid chromatography/tandem mass spectrometry analysis to quantitatively analyze sphingolipids with C20- long chain bases in human central nervous tissue.[2]

Azioni biochim/fisiol

Sphingosine (d20:1) or C20-sphingosine acts as an intermediate in the synthesis of ceramides, which are vital components of mammalian epidermis. It may be involved in regulation of epidermal differentiation.[4] C20 long chain bases-containing sphingolipids might exhibit detrimental effect on protein homeostasis and neural functions.[5]

Confezionamento

5 mL Amber Glass Screw Cap Vial (860660P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documenti section.

Se ti serve aiuto, non esitare a contattarci Servizio Clienti

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Lihong Zhao et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(42), 12962-12967 (2015-10-07)
Sphingolipids typically have an 18-carbon (C18) sphingoid long chain base (LCB) backbone. Although sphingolipids with LCBs of other chain lengths have been identified, the functional significance of these low-abundance sphingolipids is unknown. The LCB chain length is determined by serine
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
Alfred H Merrill
The Journal of biological chemistry, 277(29), 25843-25846 (2002-05-16)
P W Wertz et al.
Biochimica et biophysica acta, 1002(2), 213-217 (1989-04-03)
Sphingosines and phytosphingosines serve as intermediates in the synthesis of ceramides and glucosylceramides, which are prominent components of mammalian epidermis. In the present study, we have investigated the possibility that free sphingoid bases also may be present in epidermal tissue.
Thomas Kolter
ISRN biochemistry, 2012, 506160-506160 (2012-01-01)
Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence
Rajkumar Vutukuri et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 3932-3942 (2020-01-17)
Sphingosine 1-phosphate (S1P) signaling influences numerous cell biological mechanisms such as differentiation, proliferation, survival, migration, and angiogenesis. Intriguingly, our current knowledge is based solely on the role of S1P with an 18-carbon long-chain base length, S1P d18:1. Depending on the
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.