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860634P

Avanti

C16 Dihydroceramide (d18:0/16:0)

Avanti Research™ - A Croda Brand 860634P, powder

Sinonimo/i:

N-palmitoyl-D-erythro-sphinganine

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About This Item

Formula empirica (notazione di Hill):
C34H69NO3
Numero CAS:
5966-29-0
Peso molecolare:
539.92
Codice UNSPSC:
12352211
NACRES:
NA.25

Forma fisica

powder

Confezionamento

pkg of 1 × 10 mg (860634P-10mg)
pkg of 1 × 5 mg (860634P-5mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 860634P

Tipo di lipide

sphingolipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC

InChI

1S/C34H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h32-33,36-37H,3-31H2,1-2H3,(H,35,38)/t32-,33+/m0/s1
GCGTXOVNNFGTPQ-JHOUSYSJSA-N

Categorie correlate

Applicazioni

C16 Dihydroceramide (d18:0/16:0) is suitable for use to study the potential relevance of the changes observed in the sphingolipid composition of autophagosomes and autolysosomes in tetrahydrocannabinol (THC) treated cells or to destabilize biological membranes.

Azioni biochim/fisiol

Dihydroceramide acts as a precursor for ceramide synthesis. It has an ability to induce autophagy in the perinuclear region. Dihydroceramide affects autophagic flux and enhances the formation lipid droplets. Accumulation of C16-dihydroceramides might lead to liver injury.

Confezionamento

5 mL Amber Glass Screw Cap Vial (860634P-10mg)
5 mL Amber Glass Screw Cap Vial (860634P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Avanti

330712X

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Avanti

860518P

C18 Ceramide (d18:1/18:0)

5-Sulfosalicylic acid dihydrate suitable for electrophoresis, ≥99%

Sigma-Aldrich

S3147

5-Sulfosalicylic acid dihydrate

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Hernandez-Tiedra S, et al.
Autophagy, 12(11), 2213-2229 (2016)
Md Abdullah Al Sazzad et al.
Langmuir : the ACS journal of surfaces and colloids, 32(23), 5973-5980 (2016-05-25)
To better understand the interactions of saturated ceramides with unsaturated glycerophospholipids in bilayer membranes, we measured how palmitoyl ceramide (PCer) and dihydroceramide (dihydro-PCer, lacking the trans 4 double bond of the sphingoid base of ceramide) can interact with phosphatidylcholines (PCs)
Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model
Lee Ah young, et al.
Biochemical and biophysical research communications, 494(3-4), 460-469 (2017)
Sonia Hernández-Tiedra et al.
Autophagy, 12(11), 2213-2229 (2016-11-02)
Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ9-tetrahydrocannabinol (THC, the main

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