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860535P

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Glucosyl(β) Sphingosine (d18:1)

Avanti Research™ - A Croda Brand

Sinonimo/i:

D-glucosyl-β1-1′-D-erythro-sphingosine, Glucosylsphingosine

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5 MG
361,00 €
25 MG
1.320,00 €
50 MG
2.260,00 €

361,00 €

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Cambia visualizzazione
5 MG
361,00 €
25 MG
1.320,00 €
50 MG
2.260,00 €

About This Item

Formula empirica (notazione di Hill):
C24H47NO7
Numero CAS:
52050-17-6
Peso molecolare:
461.63
Numero MDL:
MFCD07374303
Codice UNSPSC:
12352211
NACRES:
NA.25

361,00 €

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Stato

powder

Confezionamento

pkg of 1 × 25 mg (860535P-25mg)
pkg of 1 × 5 mg (860535P-5mg)
pkg of 1 × 50 mg (860535P-50mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand

Tipo di lipide

sphingolipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O

InChI

1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18?,19-,20-,21-,22+,23+,24-/m1/s1
HHJTWTPUPVQKNA-SKXACSAKSA-N

Descrizione generale

Glucosyl sphingosine is a lyso derivative of glucosylceramide (GlcCer).[1]

Applicazioni

Glucosyl(β) Sphingosine (d18:1) or D-glucosyl-β1-1′-D-erythro-sphingosine may be used:
  • to screen lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) or tight junction (TJ) permeability in epithelial tissue[2]
  • as a standard for the quantification of glucosyl sphingosine in Gaucher patients using liquid chromatography electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS)[3]
  • as an internal standard for the quantification of lysoglucosylceramide in plasma for Gaucher disease using liquid chromatography with tandem mass spectrometry (LC-MS/MS)[4]

Azioni biochim/fisiol

Glucosyl sphingosine is a potential biomarker for Gaucher′s disease.[5] It modulates Ca2+ release in the brain microsomes.[1]

Confezionamento

5 mL Amber Glass Screw Cap Vial (860535P-25mg)
5 mL Amber Glass Screw Cap Vial (860535P-50mg)
5 mL Amber Glass Screw Cap Vial (860535P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Comunemente ordinati con questo prodotto

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Sigma-Aldrich

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CHAPS Avanti Research™ - A Croda Brand

Avanti

850500P

CHAPS

Arndt Rolfs et al.
PloS one, 8(11), e79732-e79732 (2013-11-28)
Gaucher disease (GD) is the most common lysosomal storage disorder (LSD). Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement of enzyme activity, genetic testing as well as analysis of chitotriosidase and
Emyr Lloyd-Evans et al.
The Journal of biological chemistry, 278(26), 23594-23599 (2003-04-24)
We recently demonstrated that elevation of intracellular glucosylceramide (GlcCer) levels results in increased functional Ca2+ stores in cultured neurons, and suggested that this may be due to modulation of ryanodine receptors (RyaRs) by GlcCer (Korkotian, E., Schwarz, A., Pelled, D.
Magali Pettazzoni et al.
PloS one, 12(7), e0181700-e0181700 (2017-07-28)
The biological diagnosis of sphingolipidoses currently relies on the measurement of specific enzymatic activities and/or genetic studies. Lysosphingolipids have recently emerged as potential biomarkers of sphingolipidoses and Niemann-Pick type C in plasma. We developed a sensitive and specific method enabling
Nick Dekker et al.
Blood, 118(16), e118-e127 (2011-08-27)
Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase, leads to prominent glucosylceramide accumulation in lysosomes of tissue macrophages (Gaucher cells). Here we show glucosylsphingosine, the deacylated form of glucosylceramide, to be markedly increased in plasma of symptomatic
Shu-Chih Chen-Quay et al.
Journal of pharmaceutical sciences, 98(2), 606-619 (2008-06-20)
Tight junctions (TJs) play an important role in regulating paracellular drug transport. The aim of this study was to identify lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) and/or TJ permeability in epithelial tissue. In this study, we

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