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790404P

Avanti

18:1 DGS-NTA(Ni)

Avanti Research - A Croda Brand

Sinonimo/i:

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (nickel salt); DOGS NTA

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5 MG
167,00 €
10 MG
341,00 €
25 MG
483,00 €

167,00 €


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5 MG
167,00 €
10 MG
341,00 €
25 MG
483,00 €

About This Item

Formula empirica (notazione di Hill):
C53H93N2O15Ni
Numero CAS:
Peso molecolare:
1057.00
Numero MDL:
Codice UNSPSC:
12352211
NACRES:
NA.25

167,00 €


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Descrizione

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (nickel salt)

Saggio

>99% (TLC)

Stato

powder

Confezionamento

pkg of 1 × 10 mg (790404P-10mg)
pkg of 1 × 25 mg (790404P-25mg)
pkg of 1 × 5 mg (790404P-5mg)

Produttore/marchio commerciale

Avanti Research - A Croda Brand

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Descrizione generale

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] nitrilotriacetic acid (NTA) (18:1 DGS-NTA(Ni)) is a conjugated phospholipid[1] that contains nickel.[2] NTA chelates with four of the six coordination sites present in nickel ion.[3]

Applicazioni

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (nickel salt) (18:1 DGS-NTA(Ni)) has been used:
  • in the preparation of liposomes with porphyrin-phospholipid (PoP) conjugate for protein and peptide binding studies[1]
  • in the preparation of nanosize multillamelar vesicles (NMVs) for antigen delivery studies[2]
  • as a component of small unilamellar vesicle (SUV) for planar lipid membrane (PM) preparation[4]

Azioni biochim/fisiol

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] nitrilotriacetic acid (NTA) (18:1 DGS-NTA(Ni)) is useful in structural biology especially to bind recombinant histidine tagged proteins.[1] Though useful, being nanoparticulate it has stability problems in biological samples. So NTA-lipid conjugate is majorly used as liposomes or as a coating to nanoparticle.[1] DGS-NTA (Ni) based nanosize multillamelar vesicles (NMVs) are potent vaccine delivery system.[2]

Confezionamento

5 mL Clear Glass Sealed Ampule (790404P-10mg)
5 mL Clear Glass Sealed Ampule (790404P-25mg)
5 mL Clear Glass Sealed Ampule (790404P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Comunemente ordinati con questo prodotto

Codice della classe di stoccaggio

11 - Combustible Solids


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The Journal of biological chemistry, 285(10), 7035-7044 (2009-12-22)
Her4 (ErbB-4) and Her2/neu (ErbB-2) are receptor-tyrosine kinases belonging to the epidermal growth factor receptor (EGFR) family. Crystal structures of EGFR and Her4 kinase domains demonstrate kinase dimerization and activation through an allosteric mechanism. The kinase domains form an asymmetric
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Elizabeth M Wilson-Kubalek et al.
Methods in enzymology, 481, 45-62 (2010-10-05)
Helical protein arrays offer unique advantages for structure determination by cryo-electron microscopy (cryo-EM). A single image of such an array contains a complete range of equally spaced molecular views of the underlying protein subunits, which allows a low-resolution, isotropic three-dimensional
Xuewu Zhang et al.
Cell, 125(6), 1137-1149 (2006-06-17)
The mechanism by which the epidermal growth factor receptor (EGFR) is activated upon dimerization has eluded definition. We find that the EGFR kinase domain can be activated by increasing its local concentration or by mutating a leucine (L834R) in the
Anthony L Shrout et al.
Biochemistry, 42(46), 13379-13385 (2003-11-19)
Transmembrane receptors in the signaling pathways of bacterial chemotaxis systems influence cell motility by forming noncovalent complexes with the cytoplasmic signaling proteins to regulate their activity. The requirements for receptor-mediated activation of CheA, the principal kinase of the Escherichia coli

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