700061P

24(S)-hydroxycholesterol

Avanti Research^™ - A Croda Brand

• Sinonimo/i: 5-cholestene-3β,24-diol; 24-hydroxycholest-5-en-3-ol
• Formula empirica (notazione di Hill): C₂₇H₄₆O₂
• Numero CAS: 474-73-7
• Peso molecolare: 402.65
• Numero MDL: MFCD03695560
• Codice UNSPSC: 12352211
• NACRES: NA.25

Proprietà

• Descrizione: cholest-5-ene-3β,24(S)-diol
• Saggio: >99% (TLC)
• Stato: powder
• Confezionamento: pkg of 1 × 1 mg (700061P-1mg); pkg of 1 × 5 mg (700061P-5mg)
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CC[C@H](O)C(C)C)C)(CC3)C)CC=C2C1)C
• InChI: 1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1; IOWMKBFJCNLRTC-XWXSNNQWSA-N

Descrizione

Descrizione generale

24(S)-hydroxycholesterol (24HC) is synthesized from cholesterol in brain dendrites by the action of enzyme cholesterol 24-hydroxylase (CYP46A1).[1] It is catabolized to bile acids in the liver.[2]

Applicazioni

24(S)-hydroxycholesterol has been used as an internal standard:

• in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)[3]
• in liquid chromatography with tandem mass spectrometry (LC-MS/MS) for the quantification of 27-hydroxycholesterol from colorectal tumor samples[4]
• for quantification of human plasma sterols by liquid chromatography with tandem mass spectrometry (LC MS/MS)[5]

Azioni biochim/fisiol

24(S)-hydroxycholesterol (24HC) elevated levels are reported in liver inflammation and fibrosis.[2] It is a N-methyl-D-aspartate receptor (NMDAR) modulator.[1] The levels of 24HC are potential indicators of brain development as well as pathology including Alzheimer′s disease (AD) and multiple sclerosis.[6] Polymorphism in the cholesterol 24-hydroxylase (CYP46A1) gene leads to elevated 24HC levels and toxicity. 24HC is a mediator of apoptosis and necroptosis.[7] Elevated levels of 24HC are reported in liver inflammation and fibrosis.[2]

Confezionamento

5 mL Amber Glass Screw Cap Vial (700061P-1mg)

5 mL Amber Glass Screw Cap Vial (700061P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable