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Documenti

N5757

Sigma-Aldrich

α-Naphthoflavone

≥98%

Sinonimo/i:

alpha-Naphthoflavone, 7,8-Benzoflavone

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About This Item

Formula empirica (notazione di Hill):
C19H12O2
Numero CAS:
604-59-1
Peso molecolare:
272.30
Beilstein:
210494
Numero CE:
210-071-1
Numero MDL:
MFCD00004985
Codice UNSPSC:
12352100
ID PubChem:
57654455
NACRES:
NA.22

Saggio

≥98%

Forma fisica

powder

tecniche

titration: suitable

Colore

white to yellow

Punto di fusione

153-157 °C (lit.)

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C1C=C(Oc2c1ccc3ccccc23)c4ccccc4

InChI

1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H
VFMMPHCGEFXGIP-UHFFFAOYSA-N

Informazioni sul gene

human ... ADORA3(140) , CYP1A2(1544) , PRKDC(5591)
rat ... Adora1(29290) , Adora2a(25369)

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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CypExpress™ 1A2 Cytochrome P450 human

Sigma-Aldrich

MTOXCE1A2

CypExpress™ 1A2 Cytochrome P450 human

AhR Antagonist III, GNF351 AhR Antagonist III, GNF351, is a cell-permeable, high-affinity aryl hydrocarbon receptor (AhR) antagonist (IC50 = 62 nM in mouse liver cytosol expressing humanized AhR).

Sigma-Aldrich

182707

AhR Antagonist III, GNF351

Thiotepa United States Pharmacopeia (USP) Reference Standard

USP

1664000

Thiotepa

AhR Antagonist The AhR Antagonist, also referenced under CAS 301326-22-7, controls the biological activity of AhR.

Sigma-Aldrich

182705

AhR Antagonist

3′,4′-Dimethoxyflavone

Sigma-Aldrich

D6571

3′,4′-Dimethoxyflavone

Tranylcypromine sulfate United States Pharmacopeia (USP) Reference Standard

USP

1672905

Tranylcypromine sulfate

trans-2-Phenylcyclopropylamine hydrochloride

Sigma-Aldrich

P8511

trans-2-Phenylcyclopropylamine hydrochloride

Flavone ≥99.0%

Sigma-Aldrich

F2003

Flavone

Po-Lin Liao et al.
Experimental dermatology, 21(7), 546-548 (2012-06-22)
Ageing is a complex and multifactorial process resulting in several functional and aesthetic changes to the skin. We found that α-Naphthoflavone (α-NF) concentration-dependently induced pro-collagen type I protein expression and inhibited MMP-1 protein expression, in both normal and UVB-irradiated cells.
Min Ji Kim et al.
Environmental health perspectives, 120(4), 508-514 (2012-01-21)
Epidemiological studies emphasize the possible role of persistent organic pollutants (POPs) in obesity and the metabolic syndrome. These pollutants are stored in adipose tissue (AT). Our aim was to study the effects of POPs on human adipose cells and rodent
Barbara M Zietek et al.
SLAS discovery : advancing life sciences R & D, 23(3), 283-293 (2017-12-22)
With early assessment of inhibitory properties of drug candidates and their circulating metabolites toward cytochrome P450 enzymes, drug attrition, especially later in the drug development process, can be decreased. Here we describe the development and validation of an at-line nanofractionation
Ruijuan Liu et al.
Frontiers in pharmacology, 9, 1264-1264 (2018-11-22)
Corynoline (CRL), an isoquinoline alkaloid, is the major constituent derived from Corydalis bungeana Herba, which is a well-known Chinese herbal medicine widely used in many prescriptions. The purpose of this study was to comprehensively investigate the metabolism and bioactivation of
Iain A Murray et al.
Molecular pharmacology, 79(3), 508-519 (2010-12-04)
We have characterized previously a class of aryl hydrocarbon receptor (AHR) ligand termed selective AHR modulators (SAhRMs). SAhRMs exhibit anti-inflammatory properties, including suppression of cytokine-mediated acute phase genes (e.g., Saa1), through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent
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