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861987

Sigma-Aldrich

Vancomycin hydrochloride hydrate

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About This Item

Formula empirica (notazione di Hill):
C66H75Cl2N9O24 · HCl · xH2O
Numero CAS:
123409-00-7
Peso molecolare:
1485.71 (anhydrous basis)
Numero MDL:
MFCD00151026
Codice UNSPSC:
12352005
ID PubChem:
329769449

Attività ottica

[α]21/D −28.5°, c = 1 in H2O

Temperatura di conservazione

2-8°C

Stringa SMILE

O.Cl.CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]6NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c7ccc(O)c(c7)-c8c(O)cc(O)cc8[C@H](NC6=O)C(O)=O)c3O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O[C@H]%10CC(C)(N)[C@H](O)[C@H](C)O%10)c(Cl)c2

InChI

1S/C66H75Cl2N9O24.ClH.H2O/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H;1H2/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;;/m0../s1
ZMJRZOPYYSQOFX-MHDRKALASA-N

Applicazioni

Used as selective membrane mergers to study the functional determinants of synthetic vesicle fusion

Used as an antibiotic for a variety of different studies including:
  • Impact to intestinal flora with prolonged exposure to antibiotics
  • Usefulness against antibiotic resistant bacterial strains
  • Transport of nanoparticles across phospholipid membranes

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H317,H334

Classi di pericolo

Resp. Sens. 1 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
WXBC7235V
WXBC1728V
WXBC4992V
WXBC3045V
WXBC3046V

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David J Tennent et al.
Journal of orthopaedic trauma, 30(10), 531-537 (2016-04-29)
To evaluate the effectiveness of locally applied vancomycin powder at different times postinfection in a contaminated traumatic animal model. This study used an established segmental defect rat femur model contaminated with Staphylococcus aureus UAMS-1 followed by treatment at 6 or
Jan Gessmann et al.
Tissue engineering. Part A, 24(9-10), 809-818 (2017-11-04)
Platelet-free blood plasma clots were loaded either with antibiotics (vancomycin, gentamicin, or linezolid) at concentrations of 5-300 μg/mL or with silver ions (silver acetate) at concentrations of 3.3-129 μg/mL. The release of antibiotics or silver from the clot matrix was analyzed after
Freija Van den Driessche et al.
International journal of antimicrobial agents, 49(3), 315-320 (2017-02-06)
Staphylococcus aureus biofilms are involved in a wide range of infections that are extremely difficult to treat with conventional antibiotic therapy. We aimed to identify potentiators of antibiotics against mature biofilms of S. aureus Mu50, a methicillin-resistant and vancomycin-intermediate-resistant strain.
Mia M Kiamco et al.
Biotechnology and bioengineering, 115(6), 1594-1603 (2018-02-21)
Biofilms alter their metabolism in response to environmental stress. This study explores the effect of a hyperosmotic agent-antibiotic treatment on the metabolism of Staphylococcus aureus biofilms through the use of nuclear magnetic resonance (NMR) techniques. To determine the metabolic activity
Mu Cheng et al.
Antimicrobial agents and chemotherapy, 58(11), 6819-6827 (2014-09-04)
Ramoplanin is an actinomycetes-derived antibiotic with broad-spectrum activity against Gram-positive bacteria that has been evaluated in clinical trials for the treatment of gastrointestinal vancomycin-resistant enterococci (VRE) and Clostridium difficile infections. Recent studies have proposed that ramoplanin binds to bacterial membranes
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