346357
4′-(Trifluoromethyl)-2-biphenylcarboxylic acid
97%
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About This Item
Formula condensata:
CF3C6H4C6H4CO2H
Numero CAS:
Peso molecolare:
266.22
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
NACRES:
NA.22
Prodotti consigliati
Saggio
97%
Forma fisica
solid
Punto di fusione
169-171 °C (lit.)
Gruppo funzionale
carboxylic acid
fluoro
Stringa SMILE
OC(=O)c1ccccc1-c2ccc(cc2)C(F)(F)F
InChI
1S/C14H9F3O2/c15-14(16,17)10-7-5-9(6-8-10)11-3-1-2-4-12(11)13(18)19/h1-8H,(H,18,19)
IQOMYCGTGFGDFN-UHFFFAOYSA-N
Descrizione generale
4′-(Trifluoromethyl)-2-biphenylcarboxylic acid (xenalipin) has been tested as an effective hypolipidemic agent in animal species. It has been shown to cause significant reduction in serum cholesterol and triglyceride levels in animal models and would be beneficial in therapy for hyperlipidemia. Synthesis of 4′-(trifluoromethyl)-2-biphenylcarboxylic acid (xenalipin) has been reported. Xenalipin has been synthesized in the [14C]-labelled form, with specific activity 21.0mCi/mmol, which is suitable for the metabolism and distribution studies in animals.
Applicazioni
4′-(Trifluoromethyl)-2-biphenylcarboxylic acid may be used in chemical synthesis.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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M C Lewis et al.
Atherosclerosis, 64(1), 27-35 (1987-03-01)
Xenalipin (4'-trifluoromethyl-2-biphenylcarboxylic acid) is a chemically novel compound which has been found to be an effective hypolipidemic agent in two animal species. Significant reductions in serum cholesterol and triglycerides were observed in cholesterol-cholic acid-fed rats following oral doses of 10-30
Synthesis of carbon-14 labelled xenalipin-a potential hypolipidemic agent.
Hill JA and Eaddy JF.
Journal of Labelled Compounds & Radiopharmaceuticals, 31(12), 1011-1017 (1992)
The Nickel (I) Catalyzed Coupling of a Diarylzinc with an Aryl Chloride in the Synthesis of Xenalipin.
Eaddy JF.
Organic preparations and procedures international, 27(3), 367-372 (1995)
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