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Merck
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Documenti

22019

Sigma-Aldrich

8-Quinolinol

≥99% (perchloric acid titration)

Sinonimo/i:

8-Hydroxyquinoline, 8-Oxychinolin, Oxine

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About This Item

Formula empirica (notazione di Hill):
C9H7NO
Numero CAS:
148-24-3
Peso molecolare:
145.16
Beilstein:
114512
Numero CE:
205-711-1
Numero MDL:
MFCD00006807
Codice UNSPSC:
12352100
ID PubChem:
57647959

Saggio

≥99% (perchloric acid titration)

Forma fisica

solid

Residuo alla calcinazione

≤0.05% (as SO4)

Punto di fusione

70-76 °C
72.5-74.0 °C

Anioni in tracce

chloride (Cl-): ≤20 mg/kg
sulfate (SO42-): ≤100 mg/kg

Spettro attività antibiotica

fungi

Modalità d’azione

DNA synthesis | interferes
enzyme | inhibits

Stringa SMILE

Oc1cccc2cccnc12

InChI

1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
MCJGNVYPOGVAJF-UHFFFAOYSA-N

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Descrizione generale

Chemical structure: quinolone

Avvertenze

Danger

Indicazioni di pericolo

H301,H317,H318,H360D,H410

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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Mahmud Tareq Hassan Khan et al.
Journal of medicinal chemistry, 52(1), 48-61 (2008-12-17)
In the present work, 22 compounds of the U.S. NCI compound library (size 273K) were identified as putative thermolysin binders by structure based virtual screening with the ICM software (ICM-VLS). In vitro competitive binding assays confirmed that 12 were thermolysin
Saverio Tardito et al.
Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)
This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and
Erik H J G Aarntzen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(6), 1525-1533 (2013-02-06)
Anticancer dendritic cell (DC) vaccines require the DCs to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DCs to LNs might increase vaccine efficacy
Tomoko Fukuuchi et al.
Bioorganic & medicinal chemistry letters, 16(23), 5982-5987 (2006-09-22)
Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability
María Isabel Fernández-Bachiller et al.
Journal of medicinal chemistry, 53(13), 4927-4937 (2010-06-16)
Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit cholinesterases and decrease beta-amyloid (Abeta) levels by complexation of redox-active metals, respectively. In this work, novel tacrine-8-hydroxyquinoline hybrids have been designed, synthesized, and evaluated as potential multifunctional drugs for
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