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138630

Sigma-Aldrich

1-Chloro-2,4-dinitrobenzene

97%

Sinonimo/i:

2,4-Dinitrochlorobenzene, CDNB, DNCB

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5 G
32,70 €
100 G
49,90 €
500 G
122,00 €

32,70 €

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Cambia visualizzazione
5 G
32,70 €
100 G
49,90 €
500 G
122,00 €

About This Item

Formula condensata:
ClC6H3(NO2)2
Numero CAS:
97-00-7
Peso molecolare:
202.55
Beilstein:
613161
Numero CE:
202-551-4
Numero MDL:
MFCD00007075
Codice UNSPSC:
12352100
ID PubChem:
24848362
NACRES:
NA.22

32,70 €

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Saggio

97%

Stato

solid

Limite di esplosione

22 %

P. ebollizione

315 °C (lit.)

Punto di fusione

48-50 °C (lit.)

Solubilità

alcohol: soluble (hot)
alcohol: very slightly soluble (cold)
benzene: soluble
carbon disulfide: soluble
diethyl ether: soluble
water: insoluble

Gruppo funzionale

chloro
nitro

Stringa SMILE

[O-][N+](=O)c1ccc(Cl)c(c1)[N+]([O-])=O

InChI

1S/C6H3ClN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
VYZAHLCBVHPDDF-UHFFFAOYSA-N

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Categorie correlate

Applicazioni

1-Chloro-2,4-dinitrobenzene was used in determination of relative amounts of individual glutathione S-transferases subunits in human tissues by reverse-phase HPLC[1]. It was used as contact sensitizer to study the antibacterial peptides hBD-2, -3 and -4 and LL-37 induced IL-18 protein release in human keratinocytes[2].

Azioni biochim/fisiol

2,4-dinitrochlorobenzene induces atopic dermatitis in BALB/c mice model[3].

Nota sulla preparazione

The product is dissolved in ethanol when used as glutathione S-transferase substrate and then added to a buffer to form a final concentration of 1mM in phosphate buffer (8 mL of 0.2 M KH2PO4 and 28 mL of 0.1 M Na2HPO4 per 100 mL of solution, adjusted to pH 6.5) and 4% (v/v) ethanol.

Avvertenze

Danger

Indicazioni di pericolo

H302,H310,H315,H317,H318,H410

Classi di pericolo

Acute Tox. 2 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

381.2 °F - closed cup

Punto d’infiammabilità (°C)

194 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
STBL1466
STBK6718
STBK3781
STBK3548
STBK2336

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1-Fluoro-2,4-dinitrobenzene purum p.a., ≥98.0% (GC)

Sigma-Aldrich

42085

1-Fluoro-2,4-dinitrobenzene

1,4-Dinitrobenzene 98%

Sigma-Aldrich

102369

1,4-Dinitrobenzene

François Niyonsaba et al.
Journal of immunology (Baltimore, Md. : 1950), 175(3), 1776-1784 (2005-07-22)
In addition to its physical barrier against invading microorganisms, the skin produces antimicrobial peptides, human beta-defensins (hBDs) and cathelicidin LL-37, that participate in the innate host defense. Because IL-18 is produced by keratinocytes and involved in skin diseases in which
J D Rowe et al.
The Biochemical journal, 325 ( Pt 2), 481-486 (1997-07-15)
Uncertainties about the composition and identities of glutathione S-transferases (GSTs) in human tissue have impeded studies on their biological functions. A rigorous protocol has therefore been developed to characterize the human proteins. Cytosolic GST subunits were resolved by reverse-phase HPLC
Antony Anet et al.
Journal of hazardous materials, 370, 42-53 (2018-09-15)
This study investigates Bisphenol A (BPA) induced oxidative stress that mediates the genotoxicity in in vivo model Drosophila melanogaster. The calculated LC50 for BPA was 12.35 μg/mL. The strains of D. melanogaster were reared in 0.1, 1.0, 2.5 and 5.0 μg/mL BPA
L S Tran et al.
The Journal of investigative dermatology, 134(9), 2438-2446 (2014-04-16)
We have shown that the expression of human papillomavirus type 16 E7 (HPV16.E7) protein within epithelial cells results in local immune suppression and a weak and ineffective immune response to E7 similar to that occuring in HPV-associated premalignancy and cancers.
Salik Hussain et al.
Particle and fibre toxicology, 9, 15-15 (2012-05-25)
We determined the ability of a model nanoparticle (NP) (titanium dioxide, TiO(2)) to modulate sensitization induced by a known potent dermal sensitizer (dinitrochlorobenzene) using a variant of the local lymph node assay called lymph node proliferation assay.BALB/c mice received sub-cutaneous
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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