SAB4501396
Anti-ACC1 antibody produced in rabbit
affinity isolated antibody
Szinonimák:
ACAC, ACACA, ACC-α, ACCA, Acetyl-CoA carboxylase 1
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)
About This Item
UNSPSC kód:
12352203
NACRES:
NA.41
konjugátum:
unconjugated
application:
ELISA
IHC
WB
IHC
WB
klón:
polyclonal
faj reaktivitás:
rat, human, mouse
citations:
9
technika/technikák:
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
konjugátum
unconjugated
antitest forma
affinity isolated antibody
antitest terméktípus
primary antibodies
klón
polyclonal
Forma
buffered aqueous solution
molekulatömeg
antigen 265 kDa
faj reaktivitás
rat, human, mouse
koncentráció
~1 mg/mL
technika/technikák
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI elérési szám
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... ACACA(31)
Általános leírás
Anti-ACC1 Antibody detects endogenous levels of total ACC1 protein.
Acetyl-CoA carboxylase 1 (ACC1) is expressed in adipose tissue, liver, and lactating mammary gland. It is a cytosolic enzyme. The ACC1 gene is mapped to human chromosome 17q12. It comprises biotin carboxylase (BC), carboxyl transferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The BC and CT domains are bridged together through an interaction domain (BT) and a non-catalytic central domain region (CD). The ACC1 gene encompasses three distinct promoter (PI, PII, and PIII) regions.
Immunogén
The antiserum was produced against synthesized peptide derived from human ACC1.
Immunogen Range: 46-95
Immunogen Range: 46-95
Alkalmazás
Anti-ACC1 antibody produced in rabbit has been used in immunoblotting at a dilution 1:500 and immunohistochemistry (1:50 dilution).
Biokémiai/fiziológiai hatások
Acetyl-CoA carboxylase 1 (ACC1) mediates the carboxylation of acetyl-CoA to form malonyl-CoA in an ATP-dependent manner. It plays a key role in lipogenesis, and its inhibition is regarded as one of the ways to target fatty acid synthesis, especially in metabolic disorders and metabolic syndromes. Haploinsufficiency of ACC1 gene impacts regular fatty acid metabolism. This, in turn, may lead to pathologies associated with infantile encephalitic illness and seizures.
Tulajdonságok és előnyök
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Fizikai forma
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tárolási osztály kódja
10 - Combustible liquids
WGK
nwg
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Válasszon a legfrissebb verziók közül:
Analitikai tanúsítványok (COA)
Lot/Batch Number
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Moritz Hunkeler et al.
Nature, 558(7710), 470-474 (2018-06-15)
Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis1,2. Eukaryotic acetyl-CoA carboxylases are large, homodimeric multienzymes. Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2, which is anchored to the
Claudia Tonini et al.
Nutrients, 13(6) (2021-07-03)
Bisphenol A (BPA) is an organic chemical compound widely used for manufacturing plastics. BPA exposure originates principally from the diet, but it can also originate from dermal contact. In over 90% of individuals, including pregnant women, BPA is detectable in
Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses
Tonini C, et al.
Nutrients null
Fabrizio Damiano et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1863(4), 388-398 (2018-01-19)
Acetyl-CoA carboxylase 1 (ACC1) is a cytosolic enzyme catalyzing the rate limiting step in de novo fatty acid biosynthesis. There is mounting evidence showing that ACC1 is susceptible to dysregulation and that it is over-expressed in liver diseases associated with
Hui-Xuan Wu et al.
Endocrine, 73(1), 37-46 (2021-03-22)
17q12 Deletion Syndrome is heterogeneous and the reasons remain unclear. We clarified the clinical characteristics of adulthood diabetes onset 17q12 deletion syndrome and investigated the unclear phenotype-genotype correlation. We collected the clinical history and laboratory results of a family with
Cikkek
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
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