SAB4500094

Anti-YAP antibody produced in rabbit

affinity isolated antibody

• Szinonimák: 65 kDa Yes-associated protein, YAP1, YAP65
• MDL-szám: MFCD04118707
• UNSPSC kód: 12352203
• NACRES: NA.41

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• form: buffered aqueous solution
• molekulatömeg: antigen 48 kDa
• faj reaktivitás: mouse, rat, human
• koncentráció: ~1 mg/mL
• technika/technikák: ELISA: 1:1000; western blot: 1:500-1:1000
• NCBI elérési szám: P46937
• UniProt elérési szám: P46937
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... YAP1(10413)

Leírás

Általános leírás

Anti-YAP Antibody detects endogenous levels of total YAP protein.

Yes associated protein (YAP) is a 65kDa proline-rich phosphoprotein. It is encoded by the gene mapped to human chromosome 11q22.1. The encoded protein is characterized with a WW domain, a PDZ interaction motif, an SH3 binding motif and a coiled-coil domain.

Immunogen

The antiserum was produced against synthesized peptide derived from human YAP.

Immunogen Range: 93-142

Biokémiai/fiziológiai hatások

Yes associated protein (YAP) serves as a potent mechanosensitive transcriptional activator. It plays a vital role in regulation of cancer, regeneration and organ size. Overexpression of the gene contributes to tumorigenesis in breast and liver cancers. In addition, it also promotes gallbladder cancer (GBC) cell growth via activating AXL receptor tyrosine kinase/mitogen-activated protein kinase (MAPK) pathway. Thus, it acts as a potent biomarker and therapeutic target for various cancers including, GBC and breast cancer.

Tulajdonságok és előnyök

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Fizikai forma

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: nwg
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable