SAB3500230
Anti-SARM antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Szinonimák:
Anti-SARM
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(3)
About This Item
UNSPSC kód:
12352203
NACRES:
NA.41
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
konjugátum
unconjugated
antitest forma
IgG fraction of antiserum
antitest terméktípus
primary antibodies
klón
polyclonal
form
buffered aqueous solution
molekulatömeg
predicted mol wt 80 kDa
faj reaktivitás
human, mouse
technika/technikák
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI elérési szám
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... SARM1(23098)
Általános leírás
The gene SARM1 (sterile α and TIR motif containing 1) is mapped to human chromosome 17q11. It is mainly expressed in neurons. The encoded protein belongs to the MyD88 (myeloid differentiation primary response gene 88) family of adaptor proteins. The protein contains a armadillo repeat region, SAM (sterile α motif) domains and a TIR (toll-interleukin receptor) domain. It localizes in the mitochondria as well as nucleus.
Immunogen
SARM antibody was raised against a peptide corresponding to amino acids near the C-terminus of human SARM.
Biokémiai/fiziológiai hatások
SARM1 (sterile α and TIR motif containing 1) is a TIR (toll-interleukin receptor) adaptor protein. It plays a crucial role in the immune system and TLR (toll like receptor) signaling. It interacts with PINK1 (PTEN-induced putative kinase 1) and is involved in the stabilization of PINK1 on depolarized mitochondria. During inflammation-mediated apoptosis, the protein is involved in the stabilization of nuclear lamins. SARM1 is also associated with Wallerian degeneration.
Tulajdonságok és előnyök
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Kapcsolódás
The action of this antibody can be blocked using blocking peptide SBP3500230.
Fizikai forma
Supplied in PBS with 0.02% sodium azide.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Nem találja a megfelelő terméket?
Próbálja ki a Termékválasztó eszköz. eszközt
kapcsolódó termék
Product No.
Leírás
Árazás
Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 2
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
Már rendelkezik ezzel a termékkel?
Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Xiang Zhou et al.
Developmental and comparative immunology, 39(1-2), 117-126 (2012-03-01)
Toll-like receptors (TLRs) are important pattern-recognition receptors (PRRs) that trigger innate immune response and mediate acquired immunity. Evidence has shown that SARM1 (sterile-α and TIR motif containing protein 1) is one of five TIR domain-containing adaptor proteins involved in TLRs
Hitoshi Murata et al.
Molecular biology of the cell, 24(18), 2772-2784 (2013-07-26)
Mutations in PTEN-induced putative kinase 1 (PINK1) or parkin cause autosomal recessive forms of Parkinson's disease. Recent work suggests that loss of mitochondrial membrane potential stabilizes PINK1 and that accumulated PINK1 recruits parkin from the cytoplasm to mitochondria for elimination
Laura Conforti et al.
Nature reviews. Neuroscience, 15(6), 394-409 (2014-05-21)
Axon degeneration is a prominent early feature of most neurodegenerative disorders and can also be induced directly by nerve injury in a process known as Wallerian degeneration. The discovery of genetic mutations that delay Wallerian degeneration has provided insight into
Chad R Sethman et al.
PloS one, 8(7), e70994-e70994 (2013-08-08)
Sterile alpha and armadillo-motif containing protein (SARM), a highly conserved and structurally unique member of the MyD88 family of Toll-like receptor adaptors, plays an important role in innate immunity signaling and apoptosis. Its exact mechanism of intracellular action remains unclear.
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
Lépjen kapcsolatba a szaktanácsadással