SAB2702025
Anti-ABCB1 antibody produced in rabbit
Szinonimák:
GP170, MDR1, P-GP, PGY1
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352203
NACRES:
NA.41
klón:
polyclonal
application:
WB
faj reaktivitás:
human
technika/technikák:
western blot: 1:500-1:3000
citations:
4
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
konjugátum
unconjugated
antitest forma
purified immunoglobulin
antitest terméktípus
primary antibodies
klón
polyclonal
Forma
liquid
molekulatömeg
142 kDa
faj reaktivitás
human
koncentráció
0.4 mg/mL
technika/technikák
western blot: 1:500-1:3000
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... ABCB1(5243)
Általános leírás
ABCB1 (ATP-binding cassette, subfamily B 1 gene) is also known as multidrug resistance 1 (MDR1) gene. MDR1 codes for P-glycoprotein 170 (P-gp), that is expressed at high levels in various cells and epithelial surfaces, including the epithelium of GI (gastrointestinal) tract. ABCB1 gene is located on human chromosome 7q.
Immunogén
Synthetic peptide corresponding to a region within amino acids 1 and 45 of P Glycoprotein
Alkalmazás
Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Biokémiai/fiziológiai hatások
ABCB1 (ATP-binding cassette, subfamily B 1 gene) or P-glycoprotein 170 (P-gp) participates in the development of tumors, especially in the carcinogenesis of colorectal. The encoded P-gp guards the body from environmental toxins and xenobiotics.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq]
Tulajdonságok és előnyök
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Fizikai forma
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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javasolt
Figyelmeztetés
Warning
Figyelmeztető mondatok
Óvintézkedésre vonatkozó mondatok
Veszélyességi osztályok
Aquatic Chronic 3 - Skin Sens. 1
Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
WGK 2
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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MDR1 gene polymorphisms are associated with ulcerative colitis in a cohort of Serbian patients with inflammatory bowel disease.
Dragana M, et al.
PLoS ONE, 13(3), e0194536-e0194536 (2018)
Association between MDR1 C3435T polymorphism and colorectal cancer risk.
Shan-Shan J and Wei-Juan S
Medicine, 96(51), e9428-e9428 (2017)
Yuanwei Pan et al.
Journal of controlled release : official journal of the Controlled Release Society, 330, 1106-1117 (2020-11-16)
Multidrug resistance (MDR) of cancer stem cells (CSCs) is a major hurdle to chemotherapy, and it is very important to develop CSCs-specific targeted nanocarriers for the treatment of drug resistant CSCs. In this work, we developed CSCs-specific targeted mSiO2-dPG nanocarriers
Koichi Shoji et al.
Oncology reports, 32(1), 65-70 (2014-05-21)
Fibroblast growth factor receptor 2 (FGFR2) is thought to mediate an important signaling pathway between prostate epithelial cells and stromal cells for maintenance of homeostasis in normal prostate tissue. Abnormalities of FGFR2 have been shown in advanced prostate cancer or
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