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A1104

Sigma-Aldrich

Anti-Angiopoietin-1 antibody produced in goat

affinity isolated antibody, lyophilized powder

Szinonimák:

Anti-ANG-1

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
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About This Item

MDL-szám:
MFCD06798694
UNSPSC kód:
51111800
NACRES:
NA.41

biológiai forrás

goat

Minőségi szint

200

rekombináns

expressed in goat

konjugátum

unconjugated

antitest forma

affinity isolated antibody

antitest terméktípus

primary antibodies

klón

polyclonal

form

lyophilized powder

faj reaktivitás

human

technika/technikák

immunohistochemistry: 5-15 μg/mL using cells and tissues
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL

UniProt elérési szám

Q15389

tárolási hőmérséklet

−20°C

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... ANGPT1(284)

Általános leírás

Angiopoietin 1 is an endothelial cell-specific protein that is a ligand for the TIE2 tyrosine receptor. Angiopoietin 1 is critical for mature blood vessel formation.
Angiopoietin-1 (ANG-1) activates Tie-2 signaling in endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth, and stabilization,. ANG-1 is closely related to ANG-2. Both ANG-1 and ANG-2, with their receptor Tie-2, regulate embryonic vasculogenesis and angiogenisis, adult angiogenic sprouting, as well as endothelial cell proliferation.

Immunogen

purified, NSO-derived, recombinant human ANG-1.

Alkalmazás

Goat anti-angiopoietin-1 can be used for immunohistochemistry (5-15 μg/mL), indirect ELISA (0.5-1.0 μg/mL) and western blot (0.1-0.2 μg/mL).

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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javasolt

Product No.
Leírás
Árazás

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

N Jones et al.
Nature reviews. Molecular cell biology, 2(4), 257-267 (2001-04-03)
Angiogenesis is required for normal embryonic vascular development and aberrant angiogenesis contributes to several diseases, including cancer, diabetes and tissue ischaemia. What are the molecular mechanisms that regulate this important process? The Tie family of receptors and their ligands, the
Shigetomo Fukuhara et al.
Histology and histopathology, 25(3), 387-396 (2010-01-08)
Angiopoietin (Ang) 1 is a ligand for endothelium-specific receptor tyrosine kinase Tie-2. In adult vasculature, Ang1/Tie2 signaling is thought to regulate both maintenance of vascular quiescence and promotion of angiogenesis. However, it has been unknown how Tie2 signal regulates these
L M Orre et al.
Oncogene, 32(49), 5531-5540 (2013-06-12)
S100A4 is a small calcium-binding protein that is commonly overexpressed in a range of different tumor types, and it is widely accepted that S100A4 has an important role in the process of cancer metastasis. In vitro binding assays has shown
P C Maisonpierre et al.
Science (New York, N.Y.), 277(5322), 55-60 (1997-07-04)
Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell-specific Tie2 receptor tyrosine kinase. Like vascular endothelial growth factor, Ang1 is essential for normal
B Witzenbichler et al.
The Journal of biological chemistry, 273(29), 18514-18521 (1998-07-11)
Angiopoietin-1 and its putative natural antagonist, angiopoietin-2, were recently isolated, and the critical role of angiopoietin-1 in embryogenic angiogenesis was demonstrated by targeted gene disruption. Specific biological effects of angiopoietin-1, however, have yet to be defined. In this study we
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